Drug-induced hyponatraemia in psychogenic polydipsia

Two patients with psychogenic polydipsia developed hyponatraemia, one in association with administration of hydrochlorothiazide and the other with that of tolbutamide. It is suggested that the increased fluid intake in such patients may make them more susceptible to the development of hyponatraemia...

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Bibliographic Details
Published in:Postgraduate medical journal 1976-11, Vol.52 (613), p.720-722
Main Authors: Gossain, V. V., Hagen, G. A., Sugawara, M.
Format: Article
Language:English
Subjects:
Humans
Hydrochlorothiazide - adverse effects
Hyponatremia - chemically induced
Male
Middle Aged
Psychophysiologic Disorders
Schizophrenia - complications
Thirst
Tolbutamide - adverse effects
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Summary:Two patients with psychogenic polydipsia developed hyponatraemia, one in association with administration of hydrochlorothiazide and the other with that of tolbutamide. It is suggested that the increased fluid intake in such patients may make them more susceptible to the development of hyponatraemia from thiazide or sulphonylurea compounds.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.52.613.720