Levamisole treatment of a child with severe aphthous stomatitis and neutropenia

The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugula...

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Bibliographic Details
Published in:Postgraduate medical journal 1976-08, Vol.52 (610), p.511-514
Main Authors: Verhaegen, H., De Crée, J., De Cock, W., Brugmans, J.
Format: Article
Language:English
Subjects:
Agranulocytosis - drug therapy
Child
Female
Humans
Levamisole - therapeutic use
Neutropenia - drug therapy
Recurrence
Stomatitis, Aphthous - drug therapy
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Summary:The treatment of a 12-year-old girl with a lifelone history of recurrent infections and aphthous stomatitis is reported. A profound neutropenis, first noted at the age of 2 years, occurring at least every month was observed together with multiple mouth ulcers a sore throat and swelling of the jugular glands. Levamisole, originally described as an anthelmintic, has a beneficial effect on the symptoms of recurrent aphthous stomatitis. After levamisole treatment aphthous stomatitis was milder and in the 1-year follow-up period the patient was asymptomatic several times during a phase of obvious neutrophil depression. The child no longer complained of a sore throat with swelling of the jugular glands and the recurrent staphylococcal infections of the skin disappeared. After therapy a marked increase in monocytes at the moment of neutropenia was observed.
ISSN:0032-5473
1469-0756
DOI:10.1136/pgmj.52.610.511