circadian clock system in the mammalian retina

Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24-hour rhythms is localized in th...

Full description

Saved in:
Bibliographic Details
Published in:BioEssays 2008-07, Vol.30 (7), p.624-633
Main Authors: Tosini, Gianluca, Pozdeyev, Nikita, Sakamoto, Katsuhiko, Iuvone, P. Michael
Format: Article
Language:English
Subjects:
Animals
Biological Clocks - physiology
Circadian Rhythm - physiology
CLOCK Proteins
Feedback, Physiological
Humans
Mammals - anatomy & histology
Mammals - physiology
Melatonin - chemistry
Melatonin - metabolism
Periodicity
Photoreceptor Cells - cytology
Photoreceptor Cells - metabolism
Retina - cytology
Retina - physiology
Trans-Activators - genetics
Trans-Activators - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Daily rhythms are a ubiquitous feature of living systems. Generally, these rhythms are not just passive consequences of cyclic fluctuations in the environment, but instead originate within the organism. In mammals, including humans, the master pacemaker controlling 24-hour rhythms is localized in the suprachiasmatic nuclei of the hypothalamus. This circadian clock is responsible for the temporal organization of a wide variety of functions, ranging from sleep and food intake, to physiological measures such as body temperature, heart rate and hormone release. The retinal circadian clock was the first extra-SCN circadian oscillator to be discovered in mammals and several studies have now demonstrated that many of the physiological, cellular and molecular rhythms that are present within the retina are under the control of a retinal circadian clock, or more likely a network of hierarchically organized circadian clocks that are present within this tissue. BioEssays 30:624-633, 2008.
ISSN:0265-9247
1521-1878
DOI:10.1002/bies.20777