Molecular and neural mediators of leptin action

Abstract The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological lepti...

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Bibliographic Details
Published in:Physiology & behavior 2008-08, Vol.94 (5), p.637-642
Main Authors: Robertson, Scott A, Leinninger, Gina M, Myers, Martin G
Format: Article
Language:English
Subjects:
Animals
Behavioral psychophysiology
Biological and medical sciences
Blood Glucose - metabolism
Feeding
Fundamental and applied biological sciences. Psychology
Humans
Hypothalamus
Hypothalamus - cytology
Hypothalamus - physiology
Jak2
Janus Kinase 2 - metabolism
Leptin - physiology
Leptin receptor
Neurons - physiology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Receptors, Leptin - physiology
Signal Transduction - physiology
STAT3
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Summary:Abstract The adipose tissue-derived hormone, leptin, acts via its receptor (LepRb) in the brain to regulate energy balance and neuroendocrine function. Parsing the biology of leptin requires understanding LepRb signaling and the roles for specific signaling pathways in neural and physiological leptin action. Since the leptin acts via a broadly distributed network of LepRb-expressing neurons, understanding the function of each of these LepRb neural populations will also be crucial. Here, we review the status of knowledge regarding the molecular mediators of leptin action and the neural substrate via which leptin acts to regulate physiologic processes.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2008.04.005