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Application of a column selection system and DryLab software for high-performance liquid chromatography method development
This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. The strategy employs an auto...
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| Published in: | Journal of Chromatography A 2006-07, Vol.1122 (1), p.186-193 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c542t-421c5ab30a96bbf928f3cc9d0bfe848ade43d20f130b641c98a87f6c5cefd83e3 |
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| cites | cdi_FETCH-LOGICAL-c542t-421c5ab30a96bbf928f3cc9d0bfe848ade43d20f130b641c98a87f6c5cefd83e3 |
| container_end_page | 193 |
| container_issue | 1 |
| container_start_page | 186 |
| container_title | Journal of Chromatography A |
| container_volume | 1122 |
| creator | Krisko, Ryan M. McLaughlin, Kieran Koenigbauer, Michael J. Lunte, Craig E. |
| description | This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products. |
| doi_str_mv | 10.1016/j.chroma.2006.04.065 |
| format | article |
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The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/j.chroma.2006.04.065</identifier><identifier>PMID: 16712861</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Atenolol - analysis ; Atenolol - chemistry ; Automated method development ; Biological and medical sciences ; Bupivacaine - analysis ; Bupivacaine - chemistry ; Chromatography, High Pressure Liquid - instrumentation ; Chromatography, High Pressure Liquid - methods ; Computer Simulation ; Drug Stability ; DryLab ; General pharmacology ; HPLC ; Hydrogen-Ion Concentration ; Mass Spectrometry - methods ; Medical sciences ; Pharmaceutical Preparations - analysis ; Pharmaceutical Preparations - chemistry ; Pharmacology. 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The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products.</description><subject>Analysis</subject><subject>Atenolol - analysis</subject><subject>Atenolol - chemistry</subject><subject>Automated method development</subject><subject>Biological and medical sciences</subject><subject>Bupivacaine - analysis</subject><subject>Bupivacaine - chemistry</subject><subject>Chromatography, High Pressure Liquid - instrumentation</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Computer Simulation</subject><subject>Drug Stability</subject><subject>DryLab</subject><subject>General pharmacology</subject><subject>HPLC</subject><subject>Hydrogen-Ion Concentration</subject><subject>Mass Spectrometry - methods</subject><subject>Medical sciences</subject><subject>Pharmaceutical Preparations - analysis</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Reproducibility of Results</topic><topic>Software</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Stereoisomerism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krisko, Ryan M.</creatorcontrib><creatorcontrib>McLaughlin, Kieran</creatorcontrib><creatorcontrib>Koenigbauer, Michael J.</creatorcontrib><creatorcontrib>Lunte, Craig E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krisko, Ryan M.</au><au>McLaughlin, Kieran</au><au>Koenigbauer, Michael J.</au><au>Lunte, Craig E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Application of a column selection system and DryLab software for high-performance liquid chromatography method development</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>2006-07-28</date><risdate>2006</risdate><volume>1122</volume><issue>1</issue><spage>186</spage><epage>193</epage><pages>186-193</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. 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| fulltext | fulltext |
| identifier | ISSN: 0021-9673 |
| ispartof | Journal of Chromatography A, 2006-07, Vol.1122 (1), p.186-193 |
| issn | 0021-9673 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2519830 |
| source | ScienceDirect Journals |
| subjects | Analysis Atenolol - analysis Atenolol - chemistry Automated method development Biological and medical sciences Bupivacaine - analysis Bupivacaine - chemistry Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Computer Simulation Drug Stability DryLab General pharmacology HPLC Hydrogen-Ion Concentration Mass Spectrometry - methods Medical sciences Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Reproducibility of Results Software Spectrophotometry, Ultraviolet - methods Stereoisomerism |
| title | Application of a column selection system and DryLab software for high-performance liquid chromatography method development |
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