Double-stranded RNA virus in Korean Isolate IH-2 of Trichomonas vaginalis

In this study, we describe Korean isolates of Trichomonas vaginalis infected with double-stranded (ds) RNA virus (TVV). One T. vaginalis isolate infected with TVV IH-2 evidenced weak pathogenicity in the mouse assay coupled with the persistent presence of a dsRNA, thereby indicating a hypovirulence...

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Bibliographic Details
Published in:Korean journal of parasitology 2007-06, Vol.45 (2), p.87-94
Main Authors: Kim, J.W. (Inha University, Incheon, Republic of Korea), E-mail: jwkim@inha.ac.kr, Chung, P.R. (Inha University, Incheon, Republic of Korea), Hwang, M.K. (Inha University, Incheon, Republic of Korea), Choi, E.Y. (Inha University, Incheon, Republic of Korea)
Format: Article
Language:English
Subjects:
Abscess - parasitology
Abscess - pathology
Animals
Capsid Proteins - genetics
Cloning, Molecular
Disease Models, Animal
dsRNA-dependent RNA polymerase
Female
Frameshifting, Ribosomal
Giardiavirus - classification
Giardiavirus - genetics
Giardiavirus - isolation & purification
Humans
Korea
Mice
Molecular Sequence Data
Open Reading Frames
Original
Phylogeny
ribosomal frameshift
RNA Replicase - genetics
RNA, Double-Stranded - genetics
RNA, Viral - genetics
Sequence Analysis, DNA
Sequence Homology
Totiviridae
Trichomonas Infections - virology
Trichomonas vaginalis - genetics
Trichomonas vaginalis - isolation & purification
Trichomonas vaginalis - pathogenicity
Trichomonas vaginalis - virology
Trichomonas vaginalis virus
TVV
Virulence
VIRUS
VIRUSES
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Description
Summary:In this study, we describe Korean isolates of Trichomonas vaginalis infected with double-stranded (ds) RNA virus (TVV). One T. vaginalis isolate infected with TVV IH-2 evidenced weak pathogenicity in the mouse assay coupled with the persistent presence of a dsRNA, thereby indicating a hypovirulence effect of dsRNA in T. vaginalis. Cloning and sequence analysis results revealed that the genomic dsRNA of TVV IH-2 was 4,647 bp in length and evidenced a sequence identity of 80% with the previously-described TVV 1-1 and 1-5, but only a 42% identity with TVV 2-1 and 3 isolates.
ISSN:0023-4001
1738-0006
DOI:10.3347/kjp.2007.45.2.87