Distribution of Systemic Clarithromycin to Gingiva

Background: Aggressive and recurrent forms of periodontitis are associated with infections by Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis. Because these pathogens invade tissue, they are difficult to eliminate by root planing a...

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Bibliographic Details
Published in:Journal of periodontology (1970) 2008-09, Vol.79 (9), p.1712-1718
Main Authors: Burrell, Renita C., Walters, John D.
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents - pharmacokinetics
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Chemotherapy
Clarithromycin - blood
Clarithromycin - pharmacokinetics
Clarithromycin - therapeutic use
Cohort Studies
Dental Plaque Index
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Follow-Up Studies
Gingiva - metabolism
Gingival Crevicular Fluid - secretion
Gingivitis - blood
Gingivitis - drug therapy
Gingivitis - metabolism
Humans
inflammation
Longitudinal Studies
macrolides
Male
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Periodontal Index
periodontitis
Pharmacology. Drug treatments
Prospective Studies
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Summary:Background: Aggressive and recurrent forms of periodontitis are associated with infections by Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) and Porphyromonas gingivalis. Because these pathogens invade tissue, they are difficult to eliminate by root planing alone. The use of systemic antibiotics in conjunction with root planing significantly enhances clinical and microbiologic treatment outcomes. Although it is not widely prescribed by periodontists, clarithromycin is potentially useful because it is taken up by host cells and has favorable antimicrobial activity. Methods: Experimental gingivitis was induced in eight healthy subjects at one randomly selected maxillary posterior site. The contralateral maxillary site served as the healthy control. Thereafter, subjects were administered six doses of clarithromycin, 500 mg, every 12 hours. Blood was then drawn, and samples of gingiva were harvested from both sites. The samples were extracted, and clarithromycin content was analyzed by liquid chromatography. Results: Mean clarithromycin concentrations in healthy control and inflamed gingiva (2.4 and 3.0 μg/g, respectively) were significantly higher than in serum (0.5 μg/ml; P
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2008.080013