Treatment and one-year outcome of patients with renal dysfunction across the broad spectrum of acute coronary syndromes

There are limited data on the treatment and longterm outcome of patients with renal dysfunction across the broad spectrum of acute coronary syndromes (ACS) in Canada. To examine the treatment patterns and outcome of ACS patients with renal dysfunction. In the prospective, multicentre, Canadian ACS R...

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Bibliographic Details
Published in:Canadian journal of cardiology 2006-02, Vol.22 (2), p.115-120
Main Authors: Yan, Andrew T., Yan, Raymond T., Tan, Mary, Constance, Christian, Lauzon, Claude, Zaltzman, Jeffrey, Wald, Ron, Fitchett, David, Langer, Anatoly, Goodman, Shaun G.
Format: Article
Language:English
Subjects:
Acute Disease
Aged
Aged, 80 and over
Analysis of Variance
Case-Control Studies
Clinical Studies
Cohort Studies
Coronary disease
Coronary Disease - complications
Coronary Disease - mortality
Coronary Disease - therapy
Female
Follow-Up Studies
Humans
Kidney
Logistic Models
Male
Middle Aged
Prognosis
Prospective Studies
Registries
Renal Insufficiency - complications
Renal Insufficiency - mortality
Renal Insufficiency - therapy
Survival Rate
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Summary:There are limited data on the treatment and longterm outcome of patients with renal dysfunction across the broad spectrum of acute coronary syndromes (ACS) in Canada. To examine the treatment patterns and outcome of ACS patients with renal dysfunction. In the prospective, multicentre, Canadian ACS Registry, 3510 patients hospitalized for ACS (including unstable angina, ST and non-ST elevation myocardial infarction) were categorized into four groups: normal renal function (creatinine clearance [CrCl] 90 mL/min or greater; n = 1152), mild renal dysfunction (CrCl 60 mL/min to 89 mL/min; n = 1253), moderate renal dysfunction (CrCl 30 mL/min to 59 mL/min; n = 944) and severe renal dysfunction (CrCl less than 30 mL/min; n = 161). Multivariable logistic regression analysis was performed to examine the independent prognostic value of renal dysfunction, and the association of various therapies with one-year survival. All-cause mortality at one year was 2.8%, 6.4%, 14.5% and 40.9% in patients with normal renal function, and mild, moderate and severe renal dysfunction, respectively (P for trend
ISSN:0828-282X
1916-7075
DOI:10.1016/S0828-282X(06)70249-5