Ischaemic heart disease and cholesterol There's more to heart disease than cholesterol

To reach their conclusion they included results from many trials that contributed data in one or two periods only. Because of the heterogeneity of trials a fair comparison of risk reductions in separate periods is possible only if the outcome is known for all three periods of the trials that are inc...

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Bibliographic Details
Published in:BMJ 1994-04, Vol.308 (6935), p.1038-1041
Main Authors: Bonneux, L, Barendregt, J J
Format: Article
Language:English
Subjects:
Cardiovascular disease
Cholesterol
Cholesterol - blood
Drug dosages
Health risk assessment
Heart
Humans
Hypercholesterolemia - prevention & control
Letter
Mens health
Mortality
Myocardial Ischemia - blood
Myocardial Ischemia - prevention & control
Risk Factors
Stroke
Studies
Citations: Items that cite this one
Online Access:Get full text
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Summary:To reach their conclusion they included results from many trials that contributed data in one or two periods only. Because of the heterogeneity of trials a fair comparison of risk reductions in separate periods is possible only if the outcome is known for all three periods of the trials that are included in this calculation. The estimate for the correction factor for regression dilution bias was also 1.4 in studies in which the mean did not fall - an earlier unpublished series of 1440 BUPA men and the median estimate of five published studies. 1 In reply to Sudlow and MacLeod, our analysis showed that the risk of ischaemic heart disease was almost completely reversed five years after treatment to lower serum cholesterol.
ISSN:0959-8138
1468-5833
DOI:10.1136/bmj.308.6935.1038