Risk of pneumococcal septicaemia in patients with chronic lymphoproliferative malignancies

Lymphoproliferative malignancies such as chronic lymphocytic leukaemia, myeloma, and low grade non-Hodgkin's lymphoma are associated with immune paresis. 2 Such patients are often treated with corticosteroids, and a combination of these two factors renders them vulnerable to infections with enc...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1995-07, Vol.311 (6996), p.26-27
Main Authors: Gowda, R, Razvi, F M, Summerfield, G P
Format: Article
Language:English
Subjects:
Aged
Bacterial infections
Chronic Disease
Chronic lymphocytic leukemia
Corticosteroids
Female
Hospital admissions
Humans
Immunoglobulins
Infections
Lymphoma
Lymphoproliferative disorders
Lymphoproliferative Disorders - complications
Male
Mortality
Multiple myeloma
Non Hodgkin lymphoma
Patients
Pneumococcal Infections - etiology
Risk
Sepsis
Sepsis - etiology
Spleen
Streptococcus infections
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lymphoproliferative malignancies such as chronic lymphocytic leukaemia, myeloma, and low grade non-Hodgkin's lymphoma are associated with immune paresis. 2 Such patients are often treated with corticosteroids, and a combination of these two factors renders them vulnerable to infections with encapsulated organisms such as Streptococcus pneumoniae. Case No Age (years) Sex Diagnosis Delay in admission or treatment (days) Antibiotic prophylaxis Corticosteroid treatment IgG (g/l) * Treatment before admission Outcome 1 65 M Chronic lymphocytic leukaemia 6 Yes No 2.8 Ciprofloxacin Survived 2 55 F Multiple myeloma 1 No Yes 3.2 None Survived 3 71 F Multiple myeloma 1 No Yes 7.2 None Died 4 71 M Non-Hodgkin's lymphoma 7 No Yes 11.7 None Died 5 65 M Non-Hodgkin's lymphoma 3 No Yes 6.5 None Survived 6 73 F Chronic lymphocytic leukaemia 4 No No 35.1 Ciprofloxacin Died 7 74 F Non-Hodgkin's lymphoma 2 No No 14.6 None Survived *Normal range 7.2-17.0 g/l.
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.311.6996.26