Incidence of transfusion associated B and non-A, non-B hepatitis in Italy

[...]generation enzyme linked immunosorbent assay (ELISA) was introduced in 1992 in all blood banks. Comment Our findings show a small residual risk of transfusion associated hepatitis B and indicate the effectiveness of the screening policy for antibodies to hepatitis C virus in reducing the incide...

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Bibliographic Details
Published in:BMJ 1995-09, Vol.311 (7009), p.846-847
Main Authors: Mele, Alfonso, Stroffolini, Tommaso, Catapano, Raffaele, Palumbo, Filippo, Moiraghi, Angela, Novaco, Francesca
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Blood & organ donations
Blood banks
Blood transfusion
Blood transfusions
Confidence intervals
Donor selection
Enzyme linked immunosorbent assay
Enzymes
Epidemiology
Hepacivirus
Hepatitis
Hepatitis antigens
Hepatitis B
Hepatitis B - epidemiology
Hepatitis B - transmission
Hepatitis C - epidemiology
Hepatitis C - transmission
Humans
Immunoglobulins
Incidence
Italy - epidemiology
Surveillance
Transfusion Reaction
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Summary:[...]generation enzyme linked immunosorbent assay (ELISA) was introduced in 1992 in all blood banks. Comment Our findings show a small residual risk of transfusion associated hepatitis B and indicate the effectiveness of the screening policy for antibodies to hepatitis C virus in reducing the incidence of cases of non-A, non-B hepatitis after blood transfusion. Because the viral surface antigen may be present in the serum at a low concentration or may be masked in immune complexes, it has been shown 2 that blood donors testing negative for hepatitis B surface antigen may transmit hepatitis B virus infection. 2 Transfusion with "HBsAg negative" blood is thus a potential source of infection.
ISSN:0959-8138
1468-5833
1756-1833
DOI:10.1136/bmj.311.7009.846