Immunopotentiating effect of vinca alkaloids on the antibody response to sheep red blood cells in the mouse

Evidence is presented that the vinca alkaloids (vinblastine, vincristine, and vindesine) exert an immunopotentiating effect on the antibody response to sheep red blood cells (SRBC). The primary antibody response, measured by the rosette-forming cell (RFC) and hemagglutination (HA) assays, was enhanc...

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Bibliographic Details
Published in:Journal of the National Medical Association 1981-08, Vol.73 (8), p.707-709
Main Authors: Byrd, J R, Isa, A M
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Antibody Formation - drug effects
Erythrocytes - immunology
Female
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Original Communications
Rosette Formation
Sheep
Vinca Alkaloids - pharmacology
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Summary:Evidence is presented that the vinca alkaloids (vinblastine, vincristine, and vindesine) exert an immunopotentiating effect on the antibody response to sheep red blood cells (SRBC). The primary antibody response, measured by the rosette-forming cell (RFC) and hemagglutination (HA) assays, was enhanced by vincristine and vindesine treatments. Neither drug had any effect on the secondary antibody response. Vinblastine, while having no effect on the primary response, augmented the secondary antibody response to SRBC.
ISSN:0027-9684