Differentiation of Stem Cells in the Dental Follicle

The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the period...

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Bibliographic Details
Published in:Journal of dental research 2008-08, Vol.87 (8), p.767-771
Main Authors: Yao, S., Pan, F., Prpic, V., Wise, G.E.
Format: Article
Language:English
Subjects:
Animals
ATP-Binding Cassette Transporters - metabolism
Cell Differentiation - physiology
Cells, Cultured
Dental Sac - cytology
Dental Sac - growth & development
Dental Sac - metabolism
Dentistry
Gene Expression Regulation, Developmental
Periodontal Ligament - cytology
Periodontal Ligament - growth & development
Periodontal Ligament - metabolism
Periodontium - cytology
Periodontium - growth & development
Periodontium - metabolism
Pluripotent Stem Cells - cytology
Pluripotent Stem Cells - metabolism
Rats
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Summary:The dental follicle (DF) differentiates into the periodontal ligament. In addition, it may be the precursor of other cells of the periodontium, including osteoblasts and cementoblasts. We hypothesized that stem cells may be present in the DF and be capable of differentiating into cells of the periodontium. Stem cells were identified in the DF of the rat first mandibular molar by Hoechst staining, alkaline phosphatase staining, and expression of side-population stem cell markers. These cells were shown to be able to differentiate into osteoblasts/cementoblasts, adipocytes, and neurons. Treating the DF cell population with doxorubicin, followed by incubation in an adipogenesis medium, suggested that the adipocytes originated from stem cells. Thus, a possibly puripotent stem cell population is present in the rat DF.
ISSN:0022-0345
1544-0591
DOI:10.1177/154405910808700801