Successful treatment of lupoid cutaneous leishmaniasis with glucantime and topical trichloroacetic acid (a case report)

Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margi...

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Bibliographic Details
Published in:Korean journal of parasitology 2008-09, Vol.46 (3), p.175-177
Main Authors: Nilforoushzadeh, Mohamad Ali (Isfahan University of Medical Sciences, Isfahan, Iran), Sadeghian, Giti (Isfahan University of Medical Sciences, Isfahan, Iran), E-mail: sadeghian@sdlrc.mui.ac.ir, Jaffary, Fariba (Isfahan University of Medical Sciences, Isfahan, Iran), Ziaei, Hengameh (Isfahan University of Medical Sciences, Isfahan, Iran), Shirani-Bidabad, Liela (Isfahan University of Medical Sciences, Isfahan, Iran), Mahzoni, Parvin (Isfahan University of Medical Sciences, Isfahan, Iran)
Format: Article
Language:English
Subjects:
Administration, Topical
Adult
Antiprotozoal Agents - administration & dosage
Antiprotozoal Agents - therapeutic use
Case Report
cutaneous leishmaniasis
Humans
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - pathology
Leishmanis tropica
Male
Meglumine - therapeutic use
Meglumine Antimoniate
Organometallic Compounds - therapeutic use
TCA
Trichloroacetic Acid - administration & dosage
Trichloroacetic Acid - therapeutic use
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Summary:Lupoid leishmaniasis is a unique form of cutaneous leishmaniasis characterized by unusual clinical features and a chronic relapsing course, mostly caused by infection with Leishmania tropica. In this clinical form, 1-2 yr after healing of the acute lesion, new papules and nodules appear at the margin of the remaining scar. Herein, we describe a case of this clinical form that was resistant to 2 courses of treatments: systemic glucantime and then a combination therapy with allopurinol and systemic glucantime. However, marked improvement was seen after a combination therapy with topical trichloroacetic acid solution (50%) and systemic glucantime, and there were no signs of recurrence after 1 yr of follow-up.
ISSN:0023-4001
1738-0006
DOI:10.3347/kjp.2008.46.3.175