Association of susceptibility to the development of pneumonia in the older Japanese population with haem oxygenase-1 gene promoter polymorphism

Background: Oxidative stresses including cigarette smoking are implicated in the pathogenesis of cerebrovascular diseases, which are associated with pneumonia because of frequent aspiration. Haem oxygenase-1 (HO-1) acts in cytoprotection against oxidants, provides anti-inflammatory effects, and inhi...

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Bibliographic Details
Published in:Journal of medical genetics 2006-04, Vol.43 (4), p.e17-e17
Main Authors: Yasuda, H, Okinaga, S, Yamaya, M, Ohrui, T, Higuchi, M, Shinkawa, M, Itabashi, S, Nakayama, K, Asada, M, Kikuchi, A, Shibahara, S, Sasaki, H
Format: Article
Language:English
Subjects:
Aged
Alleles
Asian Continental Ancestry Group - genetics
Atherogenesis
Atherosclerosis
Bacterial infections
Carbon monoxide
Carboxyhemoglobin - metabolism
Cardiovascular disease
cerebrovascular disease
Cerebrovascular diseases
chronic obstructive pulmonary disease
chronic pulmonary emphysema
Cigarette smoking
COPD
COPD, chronic obstructive pulmonary disease
CPE
CPE, chronic pulmonary emphysema
Electronic Letter
Electronic letters
Enzymes
Female
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genetic Testing
haem oxygenase
Heme oxygenase (decyclizing)
Heme Oxygenase-1 - genetics
HO, haem oxygenase
HO-1
HO-1, inducible haem oxygenase
Hospitals
Humans
inducible haem oxygenase
Inflammation
Japan
Male
Nosocomial infections
Older people
Oxidants
Oxidative stress
Pneumonia
Pneumonia - epidemiology
Pneumonia - genetics
Polymorphism, Genetic
Promoter Regions, Genetic
Proteins
reactive oxygen species
Risk Factors
ROS
ROS, reactive oxygen species
Smoking
TNF
TNF, tumour necrosis factor
tumour necrosis factor
Vascular diseases
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Description
Summary:Background: Oxidative stresses including cigarette smoking are implicated in the pathogenesis of cerebrovascular diseases, which are associated with pneumonia because of frequent aspiration. Haem oxygenase-1 (HO-1) acts in cytoprotection against oxidants, provides anti-inflammatory effects, and inhibits atherogenesis. A (GT)n dinucleotide repeat in the human HO-1 promoter modulates HO-1 gene expression and shows length polymorphism, which is grouped into three classes: class S (
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.2005.035824