Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases

Background: Allergic diseases such as asthma and rhinitis have closely related phenotypes and often occur with atopy. They show strong familial and intra-individual clustering, suggesting overlapping disease aetiology. Various loci and candidate genes have been suggested to underlie allergy. Many or...

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Bibliographic Details
Published in:Journal of medical genetics 2006-03, Vol.43 (3), p.e10-e10
Main Authors: Brasch-Andersen, C, Haagerup, A, Børglum, A D, Vestbo, J, Kruse, T A
Format: Article
Language:English
Subjects:
Allergies
Asthma
Asthma - genetics
atopy
Cell adhesion & migration
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 3
complex trait
Denmark
Disease
DNA - blood
DNA - genetics
DNA - isolation & purification
Electronic Letter
Genes
Genetic Linkage
Genetic Markers
genetics
Genomes
Genotype
Genotype & phenotype
Humans
Hypersensitivity, Immediate - genetics
IBD
identity by descent
IgE
immunoglobulin E
Immunoglobulins
linkage
maximum likelihood score
MLS
rhinitis
Rhinitis, Allergic, Seasonal - genetics
Studies
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Summary:Background: Allergic diseases such as asthma and rhinitis have closely related phenotypes and often occur with atopy. They show strong familial and intra-individual clustering, suggesting overlapping disease aetiology. Various loci and candidate genes have been suggested to underlie allergy. Many or all are still inconclusive. Following genome-wide scans on multiple phenotypes, we previously suggested that chromosome 3q13.12–q21.2 harbours an allergy locus. Objective: To identify candidate loci in the Danish population, two additional independent sets of sib-pair families were fine-scale mapped in candidate regions showing maximum likelihood scores (MLS) ⩾1.5 in the genome-wide scans. Results: Twenty eight microsatellite markers in a denser map on chromosome 3q were analysed in 236 allergy sib-pair families including 125 sib pairs with rhinitis. We report significant evidence for linkage to chromosome 3q13.31 for rhinitis (MLS 5.55, identity by descent (IBD) 63.9%) and atopy (increased specific immunoglobulin E) (MLS 3.71, IBD 61.7%). We obtained an MLS of 5.1 (IBD 67.3%) at 3q13.31 when sib pairs with both rhinitis and atopy were analysed. Conclusion: This study reports the first statistically significant evidence for a genetic susceptibility locus for rhinitis and to our knowledge shows the most significant evidence to date of linkage for any allergy phenotype.
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.2005.035519