Serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence

There is strong epidemiological and laboratory evidence that vitamin D may be protective against colorectal neoplasia. Therefore, we sought to assess the relationship between serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence in our ursodeoxycholic acid trial. A tot...

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Bibliographic Details
Published in:Journal of steroid biochemistry and molecular biology 2007-03, Vol.103 (3-5), p.752-756
Main Authors: Jacobs, Elizabeth T., Alberts, David S., Benuzillo, Jose, Hollis, Bruce W., Thompson, Patricia A., Martínez, María Elena
Format: Article
Language:English
Subjects:
25(OH)D
Adenoma - blood
Adenoma - epidemiology
Adenoma - pathology
Adenoma - prevention & control
Aged
Biological and medical sciences
Colorectal adenoma
Colorectal Neoplasms - blood
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - prevention & control
Diet
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical sciences
Secondary Prevention
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D - pharmacology
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Summary:There is strong epidemiological and laboratory evidence that vitamin D may be protective against colorectal neoplasia. Therefore, we sought to assess the relationship between serum 25(OH)D levels, dietary intake of vitamin D, and colorectal adenoma recurrence in our ursodeoxycholic acid trial. A total of 568 participants were randomly selected for analysis of serum 25(OH)D levels. The range of total 25(OH)D was 5.5–66.1ng/ml, with a median of 25.6ng/ml. After categorizing 25(OH)D levels into tertiles based on the population distribution, the adjusted odds ratios (95% CI) for adenoma recurrence in the second and third tertiles were 0.88 (0.56–1.39) and 0.78 (0.49–1.24), respectively. The association between serum 25(OH)D and adenoma recurrence appeared to be stronger among women than men. As compared to those below the median value, women with serum 25(OH)D levels above the median had an OR (95% CI) of 0.59 (0.30–1.16); the corresponding OR (95% CI) for men was 0.95 (0.60–1.49). Analyses by dietary vitamin D intake revealed no statistically significant associations. In summary, the results of this study show a moderate, nonsignificant inverse association between serum 25(OH)D levels and reduced risk for colorectal adenoma recurrence, particularly among women.
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2006.12.039