A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate

We have previously shown that tamoxifen+epigallocatechin gallate (EGCG) is synergistically cytotoxic towards oestrogen receptor (ER)-negative breast cancer cells. To determine if this response would correlate with significant tumour suppression in vivo , athymic nude female mice were implanted with...

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Bibliographic Details
Published in:British journal of cancer 2008-10, Vol.99 (7), p.1056-1063
Main Authors: Scandlyn, M J, Stuart, E C, Somers-Edgar, T J, Menzies, A R, Rosengren, R J
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents, Hormonal - administration & dosage
Antineoplastic Agents, Hormonal - pharmacology
Antineoplastic Agents, Hormonal - therapeutic use
Apoptosis
Aryl Hydrocarbon Hydroxylases - genetics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Blotting, Western
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer Research
Catechin - administration & dosage
Catechin - analogs & derivatives
Catechin - pharmacology
Catechin - therapeutic use
Cell growth
Cell Line, Tumor
Cytochrome P-450 CYP1B1
Cytotoxicity
Down-Regulation - drug effects
Drug Resistance
Drug Therapy, Combination
Epidemiology
Epidermal growth factor
Female
Gynecology. Andrology. Obstetrics
Humans
Kinases
Mammary gland diseases
Medical research
Medical sciences
Mice
Mice, Nude
Molecular Medicine
Oncology
Potassium
Protein expression
Protein Kinases - metabolism
Proteins
Receptor, Epidermal Growth Factor - metabolism
Receptors, Estrogen - metabolism
Tamoxifen - administration & dosage
Tamoxifen - pharmacology
Tamoxifen - therapeutic use
TOR Serine-Threonine Kinases
Translational Therapeutics
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor Receptor-1 - genetics
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Description
Summary:We have previously shown that tamoxifen+epigallocatechin gallate (EGCG) is synergistically cytotoxic towards oestrogen receptor (ER)-negative breast cancer cells. To determine if this response would correlate with significant tumour suppression in vivo , athymic nude female mice were implanted with MDA-MB-231 cells and treated with tamoxifen, EGCG, EGCG+tamoxifen, or vehicle control for 10 weeks. Tumour volume in EGCG- (25 mg kg −1 )+tamoxifen (75  μ g kg −1 )-treated mice decreased by 71% as compared with vehicle control ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604634