Renal Transplantation Is Not Associated with Regression of Left Ventricular Hypertrophy: A Magnetic Resonance Study

Patients with end-stage renal failure (ESRD) have an increased risk of premature cardiovascular (CV) disease. Left ventricular hypertrophy is an independent risk factor for CV events and death in ESRD. Renal transplantation has been associated with reduction in CV risk and echocardiographic regressi...

Full description

Saved in:
Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2008-11, Vol.3 (6), p.1807-1811
Main Authors: Patel, Rajan K, Mark, Patrick B, Johnston, Nicola, McGregor, Ellon, Dargie, Henry J, Jardine, Alan G
Format: Article
Language:English
Subjects:
Adult
Female
Humans
Hypertrophy, Left Ventricular - etiology
Hypertrophy, Left Ventricular - pathology
Hypertrophy, Left Ventricular - physiopathology
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - pathology
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - surgery
Kidney Transplantation
Magnetic Resonance Imaging
Male
Middle Aged
Renal Transplantation
Stroke Volume
Time Factors
Treatment Outcome
Ventricular Function, Left
Waiting Lists
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Patients with end-stage renal failure (ESRD) have an increased risk of premature cardiovascular (CV) disease. Left ventricular hypertrophy is an independent risk factor for CV events and death in ESRD. Renal transplantation has been associated with reduction in CV risk and echocardiographic regression of left ventricular hypertrophy. However, echocardiography overestimates LV mass in ESRD patients. Cardiac magnetic resonance (CMR) provides more detailed, volume-independent, measures of cardiac structure. Changes in LV mass measured by CMR after renal transplantation were studied. Fifty patients underwent CMR on two occasions. Twenty-five were transplanted before the second scan. CMR was performed to measure LV mass index (LVMI), ejection fraction, end-diastolic and end-systolic volumes. Changes were expressed as percentage change over time. Patients with CV events between scans (e.g., acute coronary syndrome, myocardial infarction) were excluded. All transplant patients had serum creatinine
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.01400308