Xanthones from the Botanical Dietary Supplement Mangosteen (Garcinia mangostana) with Aromatase Inhibitory Activity

Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), garcinone E (5), α-mangostin (8), and γ-mangostin (9) exhibite...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2008-07, Vol.71 (7), p.1161-1166
Main Authors: Balunas, Marcy J, Su, Bin, Brueggemeier, Robert W, Kinghorn, A. Douglas
Format: Article
Language:English
Subjects:
Anticarcinogenic Agents - chemistry
Anticarcinogenic Agents - isolation & purification
Anticarcinogenic Agents - pharmacology
aromatase
Aromatase Inhibitors - chemistry
Aromatase Inhibitors - isolation & purification
Aromatase Inhibitors - pharmacology
Biological and medical sciences
breast neoplasms
Dietary Supplements
Dose-Response Relationship, Drug
enzyme inhibition
estrogen synthase
estrogens
Food industries
Fundamental and applied biological sciences. Psychology
Garcinia
Garcinia mangostana
Garcinia mangostana - chemistry
garcinone
General pharmacology
human health
mangostin
Medical sciences
medicinal properties
Molecular Structure
oxygenases
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Research and development. New food products, dietetic foods and beverages
xanthones
Xanthones - chemistry
Xanthones - isolation & purification
Xanthones - pharmacology
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Summary:Twelve xanthone constituents of the botanical dietary supplement mangosteen (the pericarp of Garcinia mangostana) were screened using a noncellular, enzyme-based microsomal aromatase inhibition assay. Of these compounds, garcinone D (3), garcinone E (5), α-mangostin (8), and γ-mangostin (9) exhibited dose-dependent inhibitory activity. In a follow-up cell-based assay using SK-BR-3 breast cancer cells that express high levels of aromatase, the most potent of these four xanthones was γ-mangostin (9). Because xanthones may be consumed in substantial amounts from commercially available mangosteen products, the consequences of frequent intake of mangosteen botanical dietary supplements require further investigation to determine their possible role in breast cancer chemoprevention.
ISSN:0163-3864
1520-6025
DOI:10.1021/np8000255