Total antioxidants status and some hematological values in sickle cell disease patients in steady state

Congenital hemoglobin mutations may alter the delicate balance of free-radical generation and antioxidant defense systems in the red cell. Oxidative stress may thus play a role in the pathophysiology of the clinical manifestations of the disease. We assessed the total antioxidant status in steady-st...

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Bibliographic Details
Published in:Journal of the National Medical Association 2007-08, Vol.99 (8), p.891-894
Main Authors: FASOLA, Foluke, ADEDAPO, Kayode, ANETOR, John, KUTI, Modupe
Format: Article
Language:English
Subjects:
Adult
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - etiology
Anemias. Hemoglobinopathies
Antioxidants - metabolism
Biological and medical sciences
Diseases of red blood cells
Female
General aspects
Hematocrit
Hematologic and hematopoietic diseases
Humans
Leukocyte Count
Male
Medical sciences
Oxidative Stress - physiology
Platelet Count
Reticulocyte Count
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Summary:Congenital hemoglobin mutations may alter the delicate balance of free-radical generation and antioxidant defense systems in the red cell. Oxidative stress may thus play a role in the pathophysiology of the clinical manifestations of the disease. We assessed the total antioxidant status in steady-state sickle cell anemia (SCA) patients and related it to certain hematological parameters and their recent clinical history. Forty (25 males/15 females) adult SCA patients and 30 age-matched controls were studied. All patients and control subjects had total antioxidant status (TAS), hematocrit, white blood cells, platelets and reticulocyte count done. The results showed that TAS levels were about 50% lower in the SCA patients compared with the controls. Among the SCA patients, 57.1% of those with TAS levels 3 times in the past year, compared with 16% in those with TAS levels >1.00 mmol/L. Total leukocyte count and platelets were also significantly higher in the SCA patients than controls. Our data support the growing evidence that oxidative stress has a role to play in the pathophysiology of SCA and intervention aimed at increasing the antioxidant capacity of these patients may be beneficial.
ISSN:0027-9684
1943-4693