Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change

Aims:  Endometrial intraepithelial neoplasia (EIN) is a monoclonal precursor to endometrioid endometrial adenocarcinoma characterized by a geographic cluster of crowded glands with epithelial cytology altered relative to the background. It may demonstrate epithelial metaplastic changes, or arise wit...

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Bibliographic Details
Published in:Histopathology 2008-09, Vol.53 (3), p.325-332
Main Authors: Carlson, J W, Mutter, G L
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cell Differentiation
endometrial intraepithelial neoplasia
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Epithelial Cells - cytology
Epithelial Cells - pathology
Female
histopathology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
metaplasia
Metaplasia - metabolism
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
polyp
Polyps - pathology
precancer
Young Adult
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Summary:Aims:  Endometrial intraepithelial neoplasia (EIN) is a monoclonal precursor to endometrioid endometrial adenocarcinoma characterized by a geographic cluster of crowded glands with epithelial cytology altered relative to the background. It may demonstrate epithelial metaplastic changes, or arise within polyps, but the frequencies of these features as encountered in practice is unknown. The aim was to report the epithelial differentiation state and polyp context of 83 sequential EIN lesions diagnosed over a 2‐year period. Methods and results:  EIN is a rare lesion, seen in only 1.4% of endometrial biopsy specimens in a busy hospital‐based practice. Of 83 EIN cases, 39 contained metaplastic changes (18% squamous morular, 14% tubal secretory and 5% each of secretory, mucinous or ciliated change). Endometrial polyps were more likely (odds ratio 5.2, P 
ISSN:0309-0167
1365-2559
DOI:10.1111/j.1365-2559.2008.03104.x