A Whole Genome Linkage Scan Identifies Multiple Chromosomal Regions Influencing Adiposity‐Related Traits among Samoans

Summary We conducted a genome‐wide scan in 46 pedigrees, with 671 phenotyped adults, from the independent nation of Samoa to map quantitative trait loci (QTLs) for adiposity‐related phenotypes, including body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT), and fasting s...

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Bibliographic Details
Published in:Annals of human genetics 2008-11, Vol.72 (6), p.780-792
Main Authors: Dai, F., Sun, G., Åberg, K., Keighley, E. D., Indugula, S. R., Roberts, S. T., Smelser, D., Viali, S., Jin, L., Deka, R., Weeks, D. E., McGarvey, S. T.
Format: Article
Language:English
Subjects:
adiposity
Adiposity - genetics
Adolescent
Adult
Aged
Aged, 80 and over
Female
Genetic Predisposition to Disease
Genome, Human
Humans
linkage analysis
Male
Middle Aged
Obesity - genetics
Pedigree
Samoa
variance components
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Summary:Summary We conducted a genome‐wide scan in 46 pedigrees, with 671 phenotyped adults, from the independent nation of Samoa to map quantitative trait loci (QTLs) for adiposity‐related phenotypes, including body mass index (BMI), abdominal circumference (ABDCIR), percent body fat (%BFAT), and fasting serum leptin and adiponectin. A set of 378 autosomal and 14 X chromosomal microsatellite markers were genotyped in 572 of the adults. Significant genetic correlations (0.82–0.96) were detected between pairs of BMI, ABDCIR, %BFAT and leptin. Suggestive linkages were found on 13q31 (LOD = 2.30 for leptin, LOD = 2.48 for %BFAT, LOD = 2.04 for ABDCIR, and LOD = 2.09 for BMI) and on 9p22 (LOD = 3.08 for ABDCIR and LOD = 2.53 for %BFAT). Furthermore, bivariate linkage analyses indicated that the genetic regions on 9p22 (bivariate LOD 2.35–3.10, LODeq (1df) 1.88–2.59) and 13q31 (bivariate LOD 1.96–2.64, LODeq 1.52–2.21) might harbor common major genes with pleiotropic effects. Other regions showing suggestive linkage included 4q22 (LOD = 2.95) and 7p14 (LOD = 2.64) for %BFAT, 2q13 for adiponectin (LOD = 2.05) and 19q12 for BMI‐adjusted leptin (LOD = 2.03). Further fine mapping of these regions may help identify the genetic variants contributing to the development of obesity in Samoan adults.
ISSN:0003-4800
1469-1809
DOI:10.1111/j.1469-1809.2008.00462.x