Reappraisal of the role of the DRD3 gene in essential tremor

Abstract Objectives Analyze the distribution of polymorphism in the dopamine receptor D3 ( DRD3 ) gene, which was previously reported as a susceptibility risk for essential tremor (ET), in a large cohort of ET. Methods The role of 312G > A DRD3 polymorphism was analyzed using linkage analysis, as...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2008-08, Vol.14 (6), p.471-475
Main Authors: Blair, Marcia A, Ma, Shaochun, Phibbs, Fenna, Fang, John Y, Cooper, Michael K, Davis, Thomas L, Hedera, Peter
Format: Article
Language:English
Subjects:
Aged
Alleles
DRD3
Essential tremor
Essential Tremor - epidemiology
Essential Tremor - genetics
Female
Gene Frequency
Genetic Linkage - genetics
Genetics
Genotype
Glycine - physiology
Humans
Linkage Disequilibrium - genetics
Male
Middle Aged
Neurology
Pedigree
Polymorphism, Genetic - genetics
Receptors, Dopamine D3 - genetics
Serine - physiology
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Summary:Abstract Objectives Analyze the distribution of polymorphism in the dopamine receptor D3 ( DRD3 ) gene, which was previously reported as a susceptibility risk for essential tremor (ET), in a large cohort of ET. Methods The role of 312G > A DRD3 polymorphism was analyzed using linkage analysis, association study and transmission disequilibrium test in a group of 433 ET patients, and two unrelated control groups with 121 and 151 individuals. Results Allelic frequencies of glycine and serine forms of the DRD3 gene did not differ between patients and both control groups, and were in Hardy–Weinberg equilibrium. Linkage analysis identified obligatory recombinants in every large pedigree, even in those with relatively high frequency of glycine allele, thus excluding the linkage to this locus. Both alleles were transmitted with an equal likelihood to affected offspring. We also failed to replicate the relationship between glycine homozygosity and an earlier age of onset or more severe tremor course. Conclusions Our comprehensive genetic analysis in a large ET cohort strongly argues against the role of the DRD3 gene in ET pathogenesis.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2007.11.002