Carcinoma developing in ectopic pancreatic tissue in the stomach: a case report

The development of pancreatic tissue outside the confines of the main gland, without anatomic or vascular connections between them, is a congenital abnormality referred to as heterotopic pancreas. A heterotopic pancreas in the gastrointestinal tract is usually discovered incidentally and the risk of...

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Bibliographic Details
Published in:Cases journal 2008-10, Vol.1 (1), p.249-249, Article 249
Main Authors: Papaziogas, Basilios, Koutelidakis, Ioannis, Tsiaousis, Panagiotis, Panagiotopoulou, Konstantina, Paraskevas, George, Argiriadou, Helena, Atmatzidis, Stefanos, Atmatzidis, Konstantinos
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
Pancreatic cancer
Risk factors
Stomach cancer
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Summary:The development of pancreatic tissue outside the confines of the main gland, without anatomic or vascular connections between them, is a congenital abnormality referred to as heterotopic pancreas. A heterotopic pancreas in the gastrointestinal tract is usually discovered incidentally and the risk of its malignant transformation is extremely low. In this study, we describe the first case of endoepithelial carcinoma arising in a gastric heterotopic pancreas of a 56-year old woman in Greece. She presented with epigastric pain, periodic nausea and vomiting. Esophagogastroduodenoscopy revealed an ulcerated lesion in the gastric antrum, biopsies of which showed intense epithelial dysplasia with incipient malignant degeneration. The pathology report of the distal gastrectomy specimen demonstrated a 2 cm in diameter ulcerative mass in the gastric antrum. Microscopically, an endoepithelial (in situ) carcinoma of the gastric antrum was determined, which in places turned into an microinvasive endomucosal adenocarcinoma. It also incidentally demonstrated heterotopic pancreatic ducts, detected within the mucosa to the muscularis propria of the same region of the stomach, in which an endoepithelial (in situ) carcinoma was evolving. The follow-up course was uneventful 6 months postoperatively.
ISSN:1757-1626
1757-1626
DOI:10.1186/1757-1626-1-249