Coding of FM sweep trains and twitter calls in area CM of marmoset auditory cortex

• Published in: Hearing research 2008-05, Vol.239 (1), p.107-125
• Main Authors: Kajikawa, Yoshinao, de la Mothe, Lisa A., Blumell, Suzanne, Sterbing-D’Angelo, Susanne J., D’Angelo, William, Camalier, Corrie R., Hackett, Troy A.
• Format: Article
• Language: English
• Subjects: Acoustic Stimulation; Animals; Auditory; Auditory Cortex - anatomy & histology; Auditory Cortex - pathology; Auditory Cortex - physiology; Auditory Pathways; Auditory Perception; Biological and medical sciences; Brain Mapping; Callithrix; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Evoked Potentials, Auditory; Fundamental and applied biological sciences. Psychology; Learning; Medical sciences; Models, Statistical; Neurons - metabolism; Non tumoral diseases; Otorhinolaryngology. Stomatology; Primate; Sound; Sound Localization; Synchrony; Temporal; Time Factors; Vertebrates: nervous system and sense organs; Vocalization; Vocalization, Animal
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/j.heares.2008.01.015

The primate auditory cortex contains three interconnected regions (core, belt, parabelt), which are further subdivided into discrete areas. The caudomedial area (CM) is one of about seven areas in the belt region that has been the subject of recent anatomical and physiological studies conducted to define the functional organization of auditory cortex. The main goal of the present study was to examine temporal coding in area CM of marmoset monkeys using two related classes of acoustic stimuli: (1) marmoset twitter calls; and (2) frequency-modulated (FM) sweep trains modeled after the twitter call. The FM sweep trains were presented at repetition rates between 1 and 24 Hz, overlapping the natural phrase frequency of the twitter call (6–8 Hz). Multiunit recordings in CM revealed robust phase-locked responses to twitter calls and FM sweep trains. For the latter, phase-locking quantified by vector strength (VS) was best at repetition rates between 2 and 8 Hz, with a mean of about 5 Hz. Temporal response patterns were not strictly phase-locked, but exhibited dynamic features that varied with the repetition rate. To examine these properties, classification of the repetition rate from the temporal response pattern evoked by twitter calls and FM sweep trains was examined by Fisher’s linear discrimination analysis (LDA). Response classification by LDA revealed that information was encoded not only by phase-locking, but also other components of the temporal response pattern. For FM sweep trains, classification was best for repetition rates from 2 to 8 Hz. Thus, the majority of neurons in CM can accurately encode the envelopes of temporally complex stimuli over the behaviorally-relevant range of the twitter call. This suggests that CM could be engaged in processing that requires relatively precise temporal envelope discrimination, and supports the hypothesis that CM is positioned at an early stage of processing in the auditory cortex of primates.