Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist

Purpose This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles. Methods Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2008-09, Vol.25 (9-10), p.499-502
Main Authors: Bahceci, Mustafa, Ulug, Ulun
Format: Article
Language:English
Subjects:
Adult
Clinical outcomes
Female
Fertilization in Vitro - methods
Gonadotropin-Releasing Hormone - agonists
Gonadotropin-Releasing Hormone - antagonists & inhibitors
Gonadotropin-Releasing Hormone - metabolism
Gynecology
Human Genetics
Humans
Luteal Phase - drug effects
Medicine
Medicine & Public Health
Ovarian Hyperstimulation Syndrome - drug therapy
Ovaries
Ovulation Induction
Pregnancy
Pregnancy complications
Progesterone - administration & dosage
Progesterone - therapeutic use
Reproductive Medicine
Retrospective Studies
Short Communication
Sperm Injections, Intracytoplasmic
Vagina
Womens health
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Summary:Purpose This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles. Methods Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes. Results In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group. Conclusion Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-008-9269-3