Loading…
Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist
Purpose This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles. Methods Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone...
Saved in:
| Published in: | Journal of assisted reproduction and genetics 2008-09, Vol.25 (9-10), p.499-502 |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323 |
| container_end_page | 502 |
| container_issue | 9-10 |
| container_start_page | 499 |
| container_title | Journal of assisted reproduction and genetics |
| container_volume | 25 |
| creator | Bahceci, Mustafa Ulug, Ulun |
| description | Purpose
This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.
Methods
Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.
Results
In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.
Conclusion
Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation. |
| doi_str_mv | 10.1007/s10815-008-9269-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2582092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69754083</sourcerecordid><originalsourceid>FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323</originalsourceid><addsrcrecordid>eNqFks2KFDEUhQtRnHH0AdxIcKGr0vxUKslGkMGZaRgQxp9tuJ1KdWeoSsokNdJP46uashtbBXWVkPvl3HsPp6qeEvyKYCxeJ4Il4TXGsla0VTW7V50SLlgtGMP3yx1zWeOmlSfVo5RuMcZKUvawOiFSNUTK9rT6dhPmbFHo0RTDxqZsY_AWQTc671KOkF3wqA8RDYWDAU1bSBaleZpCzGiEHYK-tyajomPC-EPKBJ9jGAbboXAH0YFH291kY8punIej5OrzBfrq8hatzj-s0Jyc36BLf3OFwGfYhGWAx9WDHoZknxzOs-rTxbuP51f19fvL1fnb69pwhnNtGGuY4NDQnipLuVDAxRqTfi0VdCBZ32LSMaDCttCZRvLWcIKtUVyUd8rOqjd73Wlej7YztmwAg56iGyHudACnf694t9WbcKcplxSrReDlQSCGL3MxUo8uGTsM4G2YkxZNSzEraCFf_JNsleANluy_IFGCUsmX3s__AG_DHH3xS1PStkQ0pCkQ2UMmhpSi7X8uR7Be4qT3cdIlTnqJk14meParK8cfh_wUgO6BVEp-Y-Ox899VvwP9WNj-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>216617414</pqid></control><display><type>article</type><title>Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist</title><source>Open Access: PubMed Central</source><source>Springer Nature</source><creator>Bahceci, Mustafa ; Ulug, Ulun</creator><creatorcontrib>Bahceci, Mustafa ; Ulug, Ulun</creatorcontrib><description>Purpose
This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.
Methods
Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.
Results
In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.
Conclusion
Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-008-9269-3</identifier><identifier>PMID: 18941886</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Clinical outcomes ; Female ; Fertilization in Vitro - methods ; Gonadotropin-Releasing Hormone - agonists ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Gonadotropin-Releasing Hormone - metabolism ; Gynecology ; Human Genetics ; Humans ; Luteal Phase - drug effects ; Medicine ; Medicine & Public Health ; Ovarian Hyperstimulation Syndrome - drug therapy ; Ovaries ; Ovulation Induction ; Pregnancy ; Pregnancy complications ; Progesterone - administration & dosage ; Progesterone - therapeutic use ; Reproductive Medicine ; Retrospective Studies ; Short Communication ; Sperm Injections, Intracytoplasmic ; Vagina ; Womens health</subject><ispartof>Journal of assisted reproduction and genetics, 2008-09, Vol.25 (9-10), p.499-502</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323</citedby><cites>FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582092/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582092/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18941886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahceci, Mustafa</creatorcontrib><creatorcontrib>Ulug, Ulun</creatorcontrib><title>Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.
Methods
Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.
Results
In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.
Conclusion
Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.</description><subject>Adult</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Gonadotropin-Releasing Hormone - agonists</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Luteal Phase - drug effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ovarian Hyperstimulation Syndrome - drug therapy</subject><subject>Ovaries</subject><subject>Ovulation Induction</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Progesterone - administration & dosage</subject><subject>Progesterone - therapeutic use</subject><subject>Reproductive Medicine</subject><subject>Retrospective Studies</subject><subject>Short Communication</subject><subject>Sperm Injections, Intracytoplasmic</subject><subject>Vagina</subject><subject>Womens health</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFks2KFDEUhQtRnHH0AdxIcKGr0vxUKslGkMGZaRgQxp9tuJ1KdWeoSsokNdJP46uashtbBXWVkPvl3HsPp6qeEvyKYCxeJ4Il4TXGsla0VTW7V50SLlgtGMP3yx1zWeOmlSfVo5RuMcZKUvawOiFSNUTK9rT6dhPmbFHo0RTDxqZsY_AWQTc671KOkF3wqA8RDYWDAU1bSBaleZpCzGiEHYK-tyajomPC-EPKBJ9jGAbboXAH0YFH291kY8punIej5OrzBfrq8hatzj-s0Jyc36BLf3OFwGfYhGWAx9WDHoZknxzOs-rTxbuP51f19fvL1fnb69pwhnNtGGuY4NDQnipLuVDAxRqTfi0VdCBZ32LSMaDCttCZRvLWcIKtUVyUd8rOqjd73Wlej7YztmwAg56iGyHudACnf694t9WbcKcplxSrReDlQSCGL3MxUo8uGTsM4G2YkxZNSzEraCFf_JNsleANluy_IFGCUsmX3s__AG_DHH3xS1PStkQ0pCkQ2UMmhpSi7X8uR7Be4qT3cdIlTnqJk14meParK8cfh_wUgO6BVEp-Y-Ox899VvwP9WNj-</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Bahceci, Mustafa</creator><creator>Ulug, Ulun</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080901</creationdate><title>Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist</title><author>Bahceci, Mustafa ; Ulug, Ulun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Gonadotropin-Releasing Hormone - agonists</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Gonadotropin-Releasing Hormone - metabolism</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Luteal Phase - drug effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ovarian Hyperstimulation Syndrome - drug therapy</topic><topic>Ovaries</topic><topic>Ovulation Induction</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Progesterone - administration & dosage</topic><topic>Progesterone - therapeutic use</topic><topic>Reproductive Medicine</topic><topic>Retrospective Studies</topic><topic>Short Communication</topic><topic>Sperm Injections, Intracytoplasmic</topic><topic>Vagina</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahceci, Mustafa</creatorcontrib><creatorcontrib>Ulug, Ulun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahceci, Mustafa</au><au>Ulug, Ulun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>25</volume><issue>9-10</issue><spage>499</spage><epage>502</epage><pages>499-502</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
This study evaluated the impact of route of progesterone administration as luteal phase support on the outcome of assisted conception cycles.
Methods
Intramuscular progesterone in oil (IMP) at 100 mg daily was administered to 903 women following oocyte retrieval whereas vaginal progesterone gel (VMP) at 90 mg was administered twice daily to 1,110 women. Retrospective analysis was performed according to the type of GnRH analogue used. Implantation (IR), clinical pregnancy (CPR) and biochemical pregnancy rates (BPR) were main outcomes.
Results
In GnRH agonist cycles, neither IR, CPR or BPR differed according to the route of progesterone. However, in GnRH antagonist cycles, IR and CPR were significantly lower in VMP group compared to IMP group. BPR also was significantly higher in VMP group compared to IMP group.
Conclusion
Our results suggest that route of progesterone administration for luteal phase support can be an important prognostic factor according to the type of GnRH analogue used for controlled ovarian hyperstimulation.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>18941886</pmid><doi>10.1007/s10815-008-9269-3</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2008-09, Vol.25 (9-10), p.499-502 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2582092 |
| source | Open Access: PubMed Central; Springer Nature |
| subjects | Adult Clinical outcomes Female Fertilization in Vitro - methods Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - antagonists & inhibitors Gonadotropin-Releasing Hormone - metabolism Gynecology Human Genetics Humans Luteal Phase - drug effects Medicine Medicine & Public Health Ovarian Hyperstimulation Syndrome - drug therapy Ovaries Ovulation Induction Pregnancy Pregnancy complications Progesterone - administration & dosage Progesterone - therapeutic use Reproductive Medicine Retrospective Studies Short Communication Sperm Injections, Intracytoplasmic Vagina Womens health |
| title | Route of progesterone administration for luteal phase support may affect outcome of controlled ovarian hyperstimulation for IVF with ICSI using GnRH antagonist |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A59%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Route%20of%20progesterone%20administration%20for%20luteal%20phase%20support%20may%20affect%20outcome%20of%20controlled%20ovarian%20hyperstimulation%20for%20IVF%20with%20ICSI%20using%20GnRH%20antagonist&rft.jtitle=Journal%20of%20assisted%20reproduction%20and%20genetics&rft.au=Bahceci,%20Mustafa&rft.date=2008-09-01&rft.volume=25&rft.issue=9-10&rft.spage=499&rft.epage=502&rft.pages=499-502&rft.issn=1058-0468&rft.eissn=1573-7330&rft_id=info:doi/10.1007/s10815-008-9269-3&rft_dat=%3Cproquest_pubme%3E69754083%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c530t-c334375a42f29e2579a57b01fb89ada83f601d3a27e6adc4856c510ec9571d323%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=216617414&rft_id=info:pmid/18941886&rfr_iscdi=true |