Oral contraceptive pretreatment and half dose of ganirelix does not excessively suppress LH and may be an excellent choice for scheduling IUI cycles

• Published in: Journal of assisted reproduction and genetics 2008-08, Vol.25 (8), p.417-420
• Main Authors: Meldrum, David R., Cassidenti, Denise L., Rosen, Gregory F., Yee, Bill, Wisot, Arthur L.
• Format: Article
• Language: English
• Subjects: Adult; Birth control; Contraceptives, Oral - therapeutic use; Contraceptives, Oral, Synthetic - therapeutic use; Contraindications; Desogestrel - pharmacology; Ethinyl Estradiol - pharmacology; Female; Follicle Stimulating Hormone - metabolism; Follicles; Gonadotropin-Releasing Hormone - analogs & derivatives; Gonadotropin-Releasing Hormone - pharmacology; Gonadotropin-Releasing Hormone - therapeutic use; Gynecology; Hormone Antagonists - therapeutic use; Human Genetics; Humans; Infertility; Insemination, Artificial - instrumentation; Insemination, Artificial - methods; Luteinizing Hormone - therapeutic use; Medicine; Medicine & Public Health; Menstruation; Ovaries; Patients; Pilot projects; Pregnancy; Reproductive Medicine; Reproductive Techniques, Assisted; Scheduling; Short Communication; Sperm; Substance abuse treatment
• ISSN: 1058-0468; 1573-7330
• DOI: 10.1007/s10815-008-9244-z

Purpose To assess the effects of using a reduced dose of ganirelix with oral contraceptive pretreatment in a pilot study of COH using pure FSH for intrauterine insemination (IUI) Methods Patients received oral contraceptive (OC; 30 μg ethinyl estradiol/150 μg desogestrel) for 14–21 days and rFSH (50–225 IU/day SC) was started on day 4 after OC discontinuation. Ganirelix acetate (125 μg/day) was started with a lead follicle diameter of 14 mm. Results Of the 25 subjects who started oral contraceptives, one was cancelled due to an excessive response, and one subject was not included in the analysis because she did not receive ganirelix until the lead follicle was 18 mm. Median (range) starting FSH dose was 100 (50–225), cumulative rFSH dose was 1000 (675–2175) IU over 10 (9–17) days. Duration of ganirelix acetate treatment was 4.0 (2–5) days. Seven subjects (30.4%) delivered ten babies (three pregnancies were twins). There were no biochemical pregnancies or miscarriages. Of the 16 subjects with measurement of LH on the day of HCG administration, only one was under 0.5 mIU/ml (0.4), and only one was over 10 mIU/ml (17.7), and that subject delivered twins. Conclusion OC pretreatment afforded flexibility in scheduling while a reduced dose of ganirelix avoided excessive suppression of LH. The excellent results in this pilot study for IUI suggest this regimen could be further evaluated for scheduling IUI and IVF cycles.