Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters

To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas. Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical ch...

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Bibliographic Details
Published in:Croatian medical journal 2008-10, Vol.49 (5), p.643-649
Main Authors: Pesutić-Pisac, Valdi, Punda, Ante, Gluncić, Ivo, Bedeković, Vladimir, Pranić-Kragić, Anka, Kunac, Nenad
Format: Article
Language:English
Subjects:
Adult
Biomarkers, Tumor - analysis
Carcinoma, Papillary - chemistry
Carcinoma, Papillary - pathology
Cell Cycle Proteins - analysis
Cellular proteins
Clinical Science
Cyclin D1 - analysis
Cyclin-Dependent Kinase Inhibitor p27 - analysis
Development and progression
Female
Gene Expression Regulation, Neoplastic
Genetic aspects
Health aspects
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Middle Aged
Multivariate Analysis
Neoplasm Staging
Predictive Value of Tests
Prognosis
Risk Assessment
Risk factors
Thyroid cancer
Thyroid Neoplasms - chemistry
Thyroid Neoplasms - pathology
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Summary:To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas. Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining. Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P
ISSN:0353-9504
1332-8166
DOI:10.3325/cmj.2008.5.643