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Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters
To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas. Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical ch...
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| Published in: | Croatian medical journal 2008-10, Vol.49 (5), p.643-649 |
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| container_title | Croatian medical journal |
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| creator | Pesutić-Pisac, Valdi Punda, Ante Gluncić, Ivo Bedeković, Vladimir Pranić-Kragić, Anka Kunac, Nenad |
| description | To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas.
Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining.
Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P |
| doi_str_mv | 10.3325/cmj.2008.5.643 |
| format | article |
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Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining.
Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P<0.001) and underexpression of p27 (P<0.001) predicted lymph node metastases in papillary thyroid carcinomas. There was a significant correlation between cyclin D1 (P=0.024) and p27 (P=0.029) expression in two prognostic groups of low and high risk. Low risk group was cyclin D1 negative and p27 positive, while high risk group was cyclin D1 positive and p27 negative. Multivariate analysis confirmed that sex (P=0.041), capsular invasion (P=0.027), and p27 (P<0.001) were strong independent predictors of lymph node metastases in the high-risk group.
Immunohistochemical analysis of p27 expression may be a valuable tool for identifying risk of lymph node metastases and more aggressive behavior of papillary thyroid carcinoma.</description><identifier>ISSN: 0353-9504</identifier><identifier>EISSN: 1332-8166</identifier><identifier>DOI: 10.3325/cmj.2008.5.643</identifier><identifier>PMID: 18925698</identifier><language>eng</language><publisher>Croatia: Sveuciliste U Zagrebu</publisher><subject>Adult ; Biomarkers, Tumor - analysis ; Carcinoma, Papillary - chemistry ; Carcinoma, Papillary - pathology ; Cell Cycle Proteins - analysis ; Cellular proteins ; Clinical Science ; Cyclin D1 - analysis ; Cyclin-Dependent Kinase Inhibitor p27 - analysis ; Development and progression ; Female ; Gene Expression Regulation, Neoplastic ; Genetic aspects ; Health aspects ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Risk factors ; Thyroid cancer ; Thyroid Neoplasms - chemistry ; Thyroid Neoplasms - pathology</subject><ispartof>Croatian medical journal, 2008-10, Vol.49 (5), p.643-649</ispartof><rights>COPYRIGHT 2008 Sveuciliste U Zagrebu</rights><rights>Copyright © 2008 by the Croatian Medical Journal. All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-c24e64b36f47cddea92e4179cff4202a7ab25cf21cc3a16112adae562daa1a403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582357/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582357/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18925698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pesutić-Pisac, Valdi</creatorcontrib><creatorcontrib>Punda, Ante</creatorcontrib><creatorcontrib>Gluncić, Ivo</creatorcontrib><creatorcontrib>Bedeković, Vladimir</creatorcontrib><creatorcontrib>Pranić-Kragić, Anka</creatorcontrib><creatorcontrib>Kunac, Nenad</creatorcontrib><title>Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters</title><title>Croatian medical journal</title><addtitle>Croat Med J</addtitle><description>To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas.
Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining.
Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P<0.001) and underexpression of p27 (P<0.001) predicted lymph node metastases in papillary thyroid carcinomas. There was a significant correlation between cyclin D1 (P=0.024) and p27 (P=0.029) expression in two prognostic groups of low and high risk. Low risk group was cyclin D1 negative and p27 positive, while high risk group was cyclin D1 positive and p27 negative. Multivariate analysis confirmed that sex (P=0.041), capsular invasion (P=0.027), and p27 (P<0.001) were strong independent predictors of lymph node metastases in the high-risk group.
Immunohistochemical analysis of p27 expression may be a valuable tool for identifying risk of lymph node metastases and more aggressive behavior of papillary thyroid carcinoma.</description><subject>Adult</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Papillary - chemistry</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Cell Cycle Proteins - analysis</subject><subject>Cellular proteins</subject><subject>Clinical Science</subject><subject>Cyclin D1 - analysis</subject><subject>Cyclin-Dependent Kinase Inhibitor p27 - analysis</subject><subject>Development and progression</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Staging</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Thyroid cancer</subject><subject>Thyroid Neoplasms - chemistry</subject><subject>Thyroid Neoplasms - pathology</subject><issn>0353-9504</issn><issn>1332-8166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNptks2L1DAYxoMo7jh69SgBYW-t-W7rQVjGT1jwoufwTppOs6RNTTLq3P3DTdlBd2HJIfDmeX7hfXgQeklJzTmTb8x0UzNC2lrWSvBHaEPLuGqpUo_RhnDJq04ScYGepXRDCCNCqKfogrYdk6prN-jP7mS8m_F7imHu8cIabH8v0abkwowh4SWGwxxSdgYPYHKIuKgXWJz3EE_YQDRuDhPgMOA8nmJw_dviS8E4yCvjl8sjXv9wJiyQx-DDwRnwBRJhstnG9Bw9GcAn--J8b9H3jx--7T5X118_fdldXVdGtCpXhgmrxJ6rQTSm7y10zAradGYYBCMMGtgzaQZGjeFAFaUMerBSsR6AgiB8i97dcpfjfrK9sXOO4PUS3VR20QGcvv8yu1Efwk_NZMu4bArg8gyI4cfRpqwnl4wtUcw2HJNWnWoEL9oten0rPIC32s1DKDyzivUV7UgjOslWVf2AqpzeTiWt2Q6uzO8ZLu8YRgs-jyn44xp0epBsYkgp2uHfkpTotTi6FEevxdFSl-IUw6u70fyXn5vC_wJADcFy</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Pesutić-Pisac, Valdi</creator><creator>Punda, Ante</creator><creator>Gluncić, Ivo</creator><creator>Bedeković, Vladimir</creator><creator>Pranić-Kragić, Anka</creator><creator>Kunac, Nenad</creator><general>Sveuciliste U Zagrebu</general><general>Croatian Medical Schools</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20081001</creationdate><title>Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters</title><author>Pesutić-Pisac, Valdi ; Punda, Ante ; Gluncić, Ivo ; Bedeković, Vladimir ; Pranić-Kragić, Anka ; Kunac, Nenad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-c24e64b36f47cddea92e4179cff4202a7ab25cf21cc3a16112adae562daa1a403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Papillary - chemistry</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Cell Cycle Proteins - analysis</topic><topic>Cellular proteins</topic><topic>Clinical Science</topic><topic>Cyclin D1 - analysis</topic><topic>Cyclin-Dependent Kinase Inhibitor p27 - analysis</topic><topic>Development and progression</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Staging</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Thyroid cancer</topic><topic>Thyroid Neoplasms - chemistry</topic><topic>Thyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pesutić-Pisac, Valdi</creatorcontrib><creatorcontrib>Punda, Ante</creatorcontrib><creatorcontrib>Gluncić, Ivo</creatorcontrib><creatorcontrib>Bedeković, Vladimir</creatorcontrib><creatorcontrib>Pranić-Kragić, Anka</creatorcontrib><creatorcontrib>Kunac, Nenad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Croatian medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pesutić-Pisac, Valdi</au><au>Punda, Ante</au><au>Gluncić, Ivo</au><au>Bedeković, Vladimir</au><au>Pranić-Kragić, Anka</au><au>Kunac, Nenad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters</atitle><jtitle>Croatian medical journal</jtitle><addtitle>Croat Med J</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>49</volume><issue>5</issue><spage>643</spage><epage>649</epage><pages>643-649</pages><issn>0353-9504</issn><eissn>1332-8166</eissn><abstract>To determine the prognostic value of cell cycle regulators cyclin D1 and p27 for papillary thyroid carcinomas.
Analysis included 180 patients with papillary thyroid carcinoma who underwent surgery at Split University Hospital Center between 1999 and 2001. Clinical data were obtained from clinical charts and histopathology reports. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1. Quantification was based on the intensity and distribution of nuclear staining.
Univariate analysis showed that sex (P=0.019) and capsular invasion (P=0.010) were significant predictors of lymph node metastases, whereas age (P=0.96), histopathological variant (P=0.075), size (P=0.556) and multifocality (P=0.131) were not. Univariate analysis also showed that overexpression of cyclin D1 (P<0.001) and underexpression of p27 (P<0.001) predicted lymph node metastases in papillary thyroid carcinomas. There was a significant correlation between cyclin D1 (P=0.024) and p27 (P=0.029) expression in two prognostic groups of low and high risk. Low risk group was cyclin D1 negative and p27 positive, while high risk group was cyclin D1 positive and p27 negative. Multivariate analysis confirmed that sex (P=0.041), capsular invasion (P=0.027), and p27 (P<0.001) were strong independent predictors of lymph node metastases in the high-risk group.
Immunohistochemical analysis of p27 expression may be a valuable tool for identifying risk of lymph node metastases and more aggressive behavior of papillary thyroid carcinoma.</abstract><cop>Croatia</cop><pub>Sveuciliste U Zagrebu</pub><pmid>18925698</pmid><doi>10.3325/cmj.2008.5.643</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Croatian medical journal, 2008-10, Vol.49 (5), p.643-649 |
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| subjects | Adult Biomarkers, Tumor - analysis Carcinoma, Papillary - chemistry Carcinoma, Papillary - pathology Cell Cycle Proteins - analysis Cellular proteins Clinical Science Cyclin D1 - analysis Cyclin-Dependent Kinase Inhibitor p27 - analysis Development and progression Female Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Humans Immunohistochemistry Lymphatic Metastasis Male Middle Aged Multivariate Analysis Neoplasm Staging Predictive Value of Tests Prognosis Risk Assessment Risk factors Thyroid cancer Thyroid Neoplasms - chemistry Thyroid Neoplasms - pathology |
| title | Cyclin D1 and p27 expression as prognostic factor in papillary carcinoma of thyroid: association with clinicopathological parameters |
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