d-Amino acids in rat brain measured by liquid chromatography/tandem mass spectrometry

Previous work has established that d-amino acids including d-serine ( d-Ser) and d-aspartic acid ( d-Asp) fulfill specific biological functions in the brain. In this work, the levels and anatomical distribution of d-amino acids in rat brain were determined by using an advantageous liquid chromatogra...

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Bibliographic Details
Published in:Neuroscience letters 2008-11, Vol.445 (1), p.53-57
Main Authors: Song, Yaru, Feng, Yangzheng, Lu, Xin, Zhao, Shulin, Liu, Cheng-Wei, Liu, Yi-Ming
Format: Article
Language:English
Subjects:
Age Factors
Amino Acids - analysis
Anatomical distribution
Animals
Animals, Newborn
Biological and medical sciences
Brain - embryology
Brain - growth & development
Brain - metabolism
Chromatography, High Pressure Liquid - methods
d-Amino acids
Embryo, Mammalian
Fundamental and applied biological sciences. Psychology
Liquid chromatography/tandem mass spectrometry
Rat brain
Rats
Tandem Mass Spectrometry - methods
Vertebrates: nervous system and sense organs
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Summary:Previous work has established that d-amino acids including d-serine ( d-Ser) and d-aspartic acid ( d-Asp) fulfill specific biological functions in the brain. In this work, the levels and anatomical distribution of d-amino acids in rat brain were determined by using an advantageous liquid chromatography/tandem mass spectrometric analytical method. The study was focused on d-Ser, d-Asp, and d-glutamic acid ( d-Glu) because of the significance of l-Asp, l-Glu, and d-Ser in the nervous system. Prenatal, postnatal pups, and 90-day old rats were studied. Results indicated that d-Asp and d-Ser occurred in rat brain at the μg/g tissue level. However, d-Glu was not detected (
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2008.08.058