A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity

Airway hypersensitive reaction (AHR) is an animal model for asthma, which is caused or enhanced by environmental factors such as allergen exposure. However, the precise mechanisms that drive AHR remain unclear. We identified a novel subset of natural killer T (NKT) cells that expresses the interleuk...

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Bibliographic Details
Published in:The Journal of experimental medicine 2008-11, Vol.205 (12), p.2727-2733
Main Authors: Terashima, Asuka, Watarai, Hiroshi, Inoue, Sayo, Sekine, Etsuko, Nakagawa, Ryusuke, Hase, Koji, Iwamura, Chiaki, Nakajima, Hiroshi, Nakayama, Toshinori, Taniguchi, Masaru
Format: Article
Language:English
Subjects:
Animals
Asthma - immunology
Brief Definitive Reports
Bronchial Hyperreactivity - immunology
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
Cytokines - immunology
Disease Models, Animal
Humans
Immunoglobulin J-Chains - genetics
Immunoglobulin J-Chains - immunology
Interleukins - immunology
Lung - cytology
Lung - immunology
Lung - pathology
Mice
Mice, Inbred BALB C
Mice, Knockout
Natural Killer T-Cells - cytology
Natural Killer T-Cells - immunology
Ovalbumin - immunology
Phenotype
Receptors, Interleukin-17 - immunology
T-Lymphocyte Subsets - immunology
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Summary:Airway hypersensitive reaction (AHR) is an animal model for asthma, which is caused or enhanced by environmental factors such as allergen exposure. However, the precise mechanisms that drive AHR remain unclear. We identified a novel subset of natural killer T (NKT) cells that expresses the interleukin 17 receptor B (IL-17RB) for IL-25 (also known as IL-17E) and is essential for the induction of AHR. IL-17RB is preferentially expressed on a fraction of CD4(+) NKT cells but not on other splenic leukocyte populations tested. IL-17RB(+) CD4(+) NKT cells produce predominantly IL-13 and Th2 chemokines upon stimulation with IL-25 in vitro. IL-17RB(+) NKT cells were detected in the lung, and depletion of IL-17RB(+) NKT cells by IL-17RB-specific monoclonal antibodies or NKT cell-deficient Jalpha18(-/-) mice failed to develop IL-25-dependent AHR. Cell transfer of IL-17RB(+) but not IL-17RB(-) NKT cells into Jalpha18(-/-) mice also successfully reconstituted AHR induction. These results strongly suggest that IL-17RB(+) CD4(+) NKT cells play a crucial role in the pathogenesis of asthma.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.20080698