Association between M. pneumoniae hemolysis, attachment, and pulmonary pathogenicity

Three different groups of hemolysis mutants were produced by treatment of the M. pneumoniae FH-P24 strain with N-methyl-N-nitro-nitrosoguanidine. The first group of mutants, strains P24-L1, L2, and L11, showed wide and clear hemolytic zones, and attaching ability to erythrocytes and to hamster lung...

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Bibliographic Details
Published in:The Yale journal of biology & medicine 1983-01, Vol.56 (5-6), p.685-689
Main Author: Yayoshi, M
Format: Article
Language:English
Subjects:
Adhesiveness
Animals
Cilia - physiology
Cricetinae
Hemadsorption
Hemolysin Proteins - immunology
Hemolysis - drug effects
Humans
Lung - immunology
Lung - microbiology
Mutation
Mycoplasma pneumoniae - drug effects
Mycoplasma pneumoniae - genetics
Mycoplasma pneumoniae - pathogenicity
Mycoplasma pneumoniae - physiology
Trachea - microbiology
Virulence
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Summary:Three different groups of hemolysis mutants were produced by treatment of the M. pneumoniae FH-P24 strain with N-methyl-N-nitro-nitrosoguanidine. The first group of mutants, strains P24-L1, L2, and L11, showed wide and clear hemolytic zones, and attaching ability to erythrocytes and to hamster lung cells were the same as the properties of the parent strain and produced significant microscopic lung lesions. Mutant P24-S1 showed non-hemolysis and non-hemadsorption, yet retained the attaching ability to lung cells and produced milder lung lesions. Mutant P24-S11 showed none of those activities, did not cause any lung lesion, and was never recovered from the lungs of hamsters. A close relationship between the hemolytic ability of M. pneumoniae and the histopathogenicity in the hamster lung is suggested in this study. The attaching ability of organisms seems to be an important factor at the initial stage of infection.
ISSN:0044-0086
1551-4056