Phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction

Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free cal...

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Bibliographic Details
Published in:The Yale journal of biology & medicine 1978-01, Vol.51 (2), p.185-189
Main Authors: Pincus, J H, Insler, N F
Format: Article
Language:English
Subjects:
Animals
Anura
Calcium - metabolism
Neuromuscular Junction - drug effects
Neuromuscular Junction - metabolism
Neurotransmitter Agents - secretion
Original Contributions
Phenobarbital - pharmacology
Online Access:Get full text
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Description
Summary:Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration.
ISSN:0044-0086
1551-4056