New Generation of Inactivated Poliovirus Vaccines for Universal Immunization after Eradication of Poliomyelitis

Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, eve...

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Bibliographic Details
Published in:Clinical infectious diseases 2008-12, Vol.47 (12), p.1587-1592
Main Authors: Chumakov, Konstantin, Ehrenfeld, Ellie, Plotkin, Stanley
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cerebrospinal fluid. Meninges. Spinal cord
Codons
Disease prevention
Disease transmission
Human viral diseases
Humans
Immunity
Immunization
Inactivated poliovirus vaccine
Infectious diseases
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Oral poliovirus vaccine
Polio
Poliomyelitis
Poliomyelitis - prevention & control
Poliovirus
Poliovirus Vaccine, Inactivated - immunology
Transcriptional regulatory elements
Vaccination
Vaccines
Viral diseases
Viral diseases of the nervous system
Viruses
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Summary:Twenty years of global polio eradication efforts may soon eliminate the transmission of wild-type poliovirus. However, new information that has been learned about poliovirus, as well as the political realities of a modern world, demand that universal immunity against poliomyelitis be maintained, even after wild-type poliovirus is eradicated. Although 2 excellent vaccines have proven to be highly effective in the past, neither the live-attenuated vaccine nor the currently used inactivated vaccine are optimal for use in the posteradication era. Therefore, concerted efforts are urgently needed to develop a new generation of vaccine that is risk-free and affordable and can be produced on a global scale. Here, we discuss the desired properties of a vaccine and methods to create a new polio vaccine.
ISSN:1058-4838
1537-6591
DOI:10.1086/593310