No screening yet after a negative test for the family mutation

Screening with mammography at age 25-40 years has too low a sensitivity, may cause too many false-positive results and could possibly induce breast cancer, so it is not justified for only a slightly increased risk. 4 (3) As the results came from families with a high caseload, it is not known whether...

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Bibliographic Details
Published in:Journal of medical genetics 2007-05, Vol.44 (5), p.e79-e79
Main Author: Tilanus-Linthorst, M M A
Format: Article
Language:English
Subjects:
Adult
Age
BRCA1 Protein - genetics
BRCA2 Protein - genetics
Breast cancer
Breast Neoplasms - genetics
Correspondence
Deoxyribonucleic acid
DNA
False Negative Reactions
False Positive Reactions
Family
Female
Genetic testing
Genetic Testing - methods
Health risk assessment
Humans
Middle Aged
Mutation
Mutation - genetics
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Summary:Screening with mammography at age 25-40 years has too low a sensitivity, may cause too many false-positive results and could possibly induce breast cancer, so it is not justified for only a slightly increased risk. 4 (3) As the results came from families with a high caseload, it is not known whether such modifying genes will be present in families with BRCA1/BRCA2, with fewer cancers.
ISSN:0022-2593
1468-6244
1468-6244
DOI:10.1136/jmg.2006.048785