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Flow-Induced Arterial Remodeling Relates to Endothelial Function in the Human Forearm

Chronic changes in blood flow stimulate arterial remodeling, which contributes to the maintenance of vascular homeostasis. Experimental studies suggest that remodeling represents a response to local changes in endothelial shear stress and is nitric oxide-dependent. To investigate determinants of out...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2008-06, Vol.117 (24), p.3126-3133
Main Authors: VITA, Joseph A, HOLBROOK, Monika, PALMISANO, Joseph, SHENOUDA, Sherene M, CHUNG, William B, HAMBURG, Naomi M, ESKENAZI, Benjamin R, JOSEPH, Lija, SHAPIRA, Oz M
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Language:English
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Summary:Chronic changes in blood flow stimulate arterial remodeling, which contributes to the maintenance of vascular homeostasis. Experimental studies suggest that remodeling represents a response to local changes in endothelial shear stress and is nitric oxide-dependent. To investigate determinants of outward arterial remodeling in humans, we measured ulnar artery flow, diameter, and flow-mediated dilation before and after removal of the adjacent radial artery in 53 patients who were undergoing coronary bypass surgery (age 60+/-11 years; 13% female). Removal of the radial artery increased ulnar artery blood flow by 35% (P=0.009) and increased ulnar artery diameter by 9% (P
ISSN:0009-7322
1524-4539
DOI:10.1161/circulationaha.108.778472