New advances in breast cancer metastasis

Altogether, this novel information clearly indicates that SATB1 is an important step in the cascade that initiates EMT and, therefore, a justified target for therapeutic intervention. Since SATB1 expression in cancer cells necessarily alters the gene-expression profile to promote tumor growth and me...

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Bibliographic Details
Published in:Women's health (London, England) England), 2008-11, Vol.4 (6), p.547-549
Main Authors: Russo, Jose, Han, Hye-Jung, Kohwi, Yoshinori, Kohwi-Shigematsu, Terumi
Format: Article
Language:English
Subjects:
Angiogenesis
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Cadherins - genetics
Cancer therapies
Care and treatment
Cell adhesion & migration
Development and progression
DNA microarrays
Female
Genetic aspects
Genetic regulation
Genomes
Humans
Matrix Attachment Region Binding Proteins - genetics
Matrix Attachment Region Binding Proteins - metabolism
Mortality
Neoplasm Metastasis - genetics
Prognosis
Proteins
Survival analysis
Tumors
Womens health
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Summary:Altogether, this novel information clearly indicates that SATB1 is an important step in the cascade that initiates EMT and, therefore, a justified target for therapeutic intervention. Since SATB1 expression in cancer cells necessarily alters the gene-expression profile to promote tumor growth and metastasis, SATB1 can serve as a sentinel, indicating that cells have acquired the aggressive phenotype.
ISSN:1745-5057
1745-5065
DOI:10.2217/17455057.4.6.547