Structural diversity of mitochondria: functional implications

Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diff...

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Published in:Annals of the New York Academy of Sciences 2008-12, Vol.1147 (1), p.171-179
Main Author: Mannella, Carmen A
Format: Article
Language:English
Subjects:
Apoptosis
Intracellular Membranes - ultrastructure
Mitochondria - ultrastructure
Oxidative Stress
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description Mitochondria display considerable structural diversity particularly in terms of the folding of the energy-transducing inner membrane. The hypothesis is forwarded that the topology of the mitochondrial inner membrane is not random but rather is a regulated cell parameter. Its effects on internal diffusion of metabolites and soluble proteins can influence such mitochondrial processes as ATP production and protein release during apoptosis. Progress toward understanding the factors that control mitochondrial inner-membrane curvature and dynamics (fusion and fission) is summarized, with a focus on remodeling events associated with apoptosis and oxidative stress.
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source Wiley-Blackwell Read & Publish Collection
subjects Apoptosis
Intracellular Membranes - ultrastructure
Mitochondria - ultrastructure
Oxidative Stress
title Structural diversity of mitochondria: functional implications
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