Assessing the Relationship Between Central Corneal Thickness and Retinal Nerve Fiber Layer Thickness in Healthy Subjects

Purpose To determine the relationship between central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness obtained by scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Dublin, California, USA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelbe...

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Bibliographic Details
Published in:American journal of ophthalmology 2008-10, Vol.146 (4), p.561-566
Main Authors: Mumcuoglu, Tarkan, Townsend, Kelly A, Wollstein, Gadi, Ishikawa, Hiroshi, Bilonick, Richard A, Sung, Kyung Rim, Kagemann, Larry, Schuman, Joel S
Format: Article
Language:English
Subjects:
Algorithms
Biological and medical sciences
Body Weights and Measures
Colleges & universities
Confidence intervals
Cornea - diagnostic imaging
Cross-Sectional Studies
Dietary fiber
Family medical history
Female
Glaucoma
Gonioscopy
Health Insurance Portability & Accountability Act 1996-US
Humans
Hypertension
Interferometry - methods
Intraocular Pressure
Lasers
Male
Medical imaging
Medical sciences
Middle Aged
Miscellaneous
Nerve Fibers
Ophthalmology
Ophthalmoscopy - methods
Retina
Retinal Ganglion Cells - cytology
Retrospective Studies
Software
Standard deviation
Tomography, Optical Coherence - methods
Ultrasonography
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Summary:Purpose To determine the relationship between central corneal thickness (CCT) and retinal nerve fiber layer (RNFL) thickness obtained by scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Dublin, California, USA), confocal scanning laser ophthalmoscopy (HRT II; Heidelberg Engineering, Heidelberg, Germany), and optical coherence tomography (Stratus OCT; Carl Zeiss Meditec). Design Multicenter clinical trial, retrospective cross-sectional study. Methods One hundred and nine healthy subjects from the Advanced Imaging in Glaucoma Study were enrolled in this study. All subjects had a standard clinical examination, including visual field (VF) and good-quality scans from all three imaging devices. CCT was measured using an ultrasonic pachymeter. A linear mixed-effects model was used to assess the relationship between RNFL thickness and CCT, accounting for clustering of eyes within subjects, testing site, ethnicity, family history of glaucoma, axial length intraocular pressure, and VF global indices. Results For OCT and GDx, there was a slight nonstatistically significant positive relationship between CCT and RNFL thickness. For HRT, there was a slight nonstatistically significant negative relationship between CCT and RNFL thickness. Relationships for each device were found to differ between sites. Conclusions CCT was not statistically significantly related to RNFL thickness in healthy eyes.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2008.05.038