Sarcoidosis presenting with prolonged fever in a patient with sickle cell anemia

Although the leading causes of fever and pulmonary infiltrates in sickle cell patients are acute bacterial pneumonia and the acute chest syndrome, the former is usually responsive to antibiotics and not protracted, and the clinical course of the latter is short and self-limited. A patient with sickl...

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Bibliographic Details
Published in:Journal of the National Medical Association 1995-11, Vol.87 (11), p.826-828
Main Authors: CHAN, E. D, TERADA, L. S, SCHWARZ, M. I
Format: Article
Language:English
Subjects:
Adult
African Americans
Anemia, Sickle Cell - complications
Biological and medical sciences
Female
Fever of Unknown Origin - etiology
Humans
Medical sciences
Sarcoidosis - complications
Sarcoidosis - drug therapy
Sarcoidosis - epidemiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Although the leading causes of fever and pulmonary infiltrates in sickle cell patients are acute bacterial pneumonia and the acute chest syndrome, the former is usually responsive to antibiotics and not protracted, and the clinical course of the latter is short and self-limited. A patient with sickle cell anemia presented with fever and pulmonary infiltrates of several weeks duration that were unresponsive to antibiotics. Gross endobronchial abnormalities were noted on bronchoscopy, and the biopsies were consistent with sarcoidosis. The diagnosis of sarcoidosis can be difficult to establish in a patient with sickle cell anemia and protracted fever since both disorders are associated with chronic interstitial changes on the chest radiograph as well as restrictive physiology.
ISSN:0027-9684
1943-4693