Congenital Abnormalities and Acute Leukemia among Children with Down Syndrome: A Children's Oncology Group Study

Children with Down syndrome, due to their heightened risk of leukemia and increased prevalence of congenital abnormalities, comprise a valuable population in which to study etiology. A Children's Oncology Group study investigated the causes of childhood leukemia in children with Down syndrome d...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2008-10, Vol.17 (10), p.2572-2577
Main Authors: LINABERY, Amy M, BLAIR, Cindy K, GAMIS, Alan S, OLSHAN, Andrew F, HEEREMA, Nyla A, ROSS, Julie A
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
children
Chromosome aberrations
congenital abnormalities
Congenital Abnormalities - genetics
Down syndrome
Down Syndrome - genetics
epidemiology
Female
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Interviews as Topic
leukemia
Leukemia, Myeloid, Acute - genetics
Logistic Models
Male
Medical genetics
Medical sciences
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Risk Factors
Tumors
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Summary:Children with Down syndrome, due to their heightened risk of leukemia and increased prevalence of congenital abnormalities, comprise a valuable population in which to study etiology. A Children's Oncology Group study investigated the causes of childhood leukemia in children with Down syndrome diagnosed at ages 0 to 19 years during the period 1997-2002. Telephone interviews were completed with mothers of 158 cases [ n = 97 acute lymphoblastic leukemia (ALL) and n = 61 acute myeloid leukemia (AML)] and 173 controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed via unconditional logistic regression to evaluate the association between congenital abnormalities and acute leukemia overall, and ALL and AML analyzed separately. The results do not provide evidence for an association among the index children (OR Combined , 0.74; 95% CI, 0.45-1.23; OR ALL , 0.67; 95% CI, 0.38-1.20; OR AML ,1.03; 95% CI, 0.49-2.16) or their siblings (OR Combined , 1.23; 95% CI, 0.71-2.13; OR ALL , 1.12; 95% CI, 0.60-2.09; OR AML , 1.60; 95% CI, 0.66-3.86), suggesting congenital malformations do not confer additional risk of leukemia beyond the risk attributable to trisomy 21 in this population. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2572–7)
ISSN:1055-9965
1538-7755
DOI:10.1158/1055-9965.EPI-08-0284