A chromatic explosion: the development and future of multiparameter flow cytometry

Summary Multiparameter flow cytometry has matured tremendously since the 1990s, giving rise to a technology that allows us to study the immune system in unprecedented detail. In this article, we review the development of hardware, reagents, and data analysis tools for multiparameter flow cytometry a...

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Bibliographic Details
Published in:Immunology 2008-12, Vol.125 (4), p.441-449
Main Authors: Chattopadhyay, Pratip K., Hogerkorp, Carl‐Magnus, Roederer, Mario
Format: Article
Language:English
Subjects:
Animals
Coloring Agents
data analysis
Equipment Design
flow cytometry
Flow Cytometry - methods
Flow Cytometry - trends
fluorochromes
Forecasting
Humans
Immune System Diseases - diagnosis
Review
Statistics as Topic
T cells
tetramers
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Summary:Summary Multiparameter flow cytometry has matured tremendously since the 1990s, giving rise to a technology that allows us to study the immune system in unprecedented detail. In this article, we review the development of hardware, reagents, and data analysis tools for multiparameter flow cytometry and discuss future advances in the field. Finally, we highlight new applications that use this technology to reveal previously unappreciated aspects of cell biology and immunity.
ISSN:0019-2805
1365-2567
DOI:10.1111/j.1365-2567.2008.02989.x