Extrapulmonary small cell carcinoma of the liver: clinicopathological and immunohistochemical findings

Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically,...

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Bibliographic Details
Published in:Yonsei medical journal 2007-12, Vol.48 (6), p.1066-1071
Main Authors: Choi, Suk Jin, Kim, Joon Mee, Han, Jee Young, Ahn, Seung Ik, Kim, Jin-Soo, Kim, Lucia, Park, In Suh, Chu, Young Chae
Format: Article
Language:English
Subjects:
Aged, 80 and over
Carcinoma, Small Cell - metabolism
Carcinoma, Small Cell - pathology
Case Report
CD56 Antigen - analysis
Chromogranins - analysis
Female
Humans
Immunohistochemistry
Liver - chemistry
Liver - pathology
Liver Neoplasms - metabolism
Liver Neoplasms - pathology
Lung Neoplasms - pathology
Phosphopyruvate Hydratase - analysis
Synaptophysin - analysis
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Summary:Patients with primary small cell carcinoma of the liver have rarely been described in medical literature. Knowledge of clinical, pathological and immunohistochemical properties remains limited. We described an 82-year-old female patient with primary small cell carcinoma of the liver. Histologically, the tumor showed typical morphology of a pulmonary small cell carcinoma. Immunohistochemically, the tumor revealed neuroendocrine differentiation; positive reaction for chromogranin, synaptophysin, CD56, and neuron specific enolase. The tumor was also positive for TTF-1 and c-kit but completely negative for hepatocyte, carcinoembryonic antigen, cytokeratin 7; 19; and 20. Herein, we discussed the clinical, pathological and immunohistochemical findings of extrapulmonary small cell carcinoma of the liver and reviewed the relevant literature.
ISSN:0513-5796
1976-2437
DOI:10.3349/ymj.2007.48.6.1066