Versatile Pd(II)-Catalyzed C−H Activation/Aryl−Aryl Coupling of Benzoic and Phenyl Acetic Acids

The use of aryltrifluoroborates as coupling partners and O2 as the oxidant substantially improves the scope and practicality of the Pd-catalyzed C−H activation/C−C coupling reaction. The newly discovered protocol made possible, for the first time, the ortho-coupling of electron-deficient arenes and...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2008-12, Vol.130 (52), p.17676-17677
Main Authors: Wang, Dong-Hui, Mei, Tian-Sheng, Yu, Jin-Quan
Format: Article
Language:English
Subjects:
Benzoates - chemistry
Biphenyl Compounds - chemical synthesis
Borates - chemistry
Catalysis
Organometallic Compounds - chemistry
Palladium - chemistry
Phenylacetates - chemistry
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Summary:The use of aryltrifluoroborates as coupling partners and O2 as the oxidant substantially improves the scope and practicality of the Pd-catalyzed C−H activation/C−C coupling reaction. The newly discovered protocol made possible, for the first time, the ortho-coupling of electron-deficient arenes and phenyl acetic acids with organometallic reagents.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja806681z