Approaching the cellular mechanism that supports the intercellular spread of Tobacco mosaic virus

Plant viruses spread cell-to-cell in infected plants by exploiting plasmodesmata (PD), gatable channels in the cell wall that provide cytoplasmic passageways for the trafficking of informational macromolecules. Since it became known that the intercellular spread of Tobacco mosaic virus (TMV) depends...

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Bibliographic Details
Published in:Plant signaling & behavior 2009-01, Vol.4 (1), p.35-38
Main Authors: Sambade, Adrian, Heinlein, Manfred
Format: Article
Language:English
Subjects:
Addendum
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cellular Biology
Cycle
Landes
Life Sciences
Organogenesis
Proteins
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Summary:Plant viruses spread cell-to-cell in infected plants by exploiting plasmodesmata (PD), gatable channels in the cell wall that provide cytoplasmic passageways for the trafficking of informational macromolecules. Since it became known that the intercellular spread of Tobacco mosaic virus (TMV) depends on virus-encoded movement protein (MP), the mechanism by which this protein mediates in the targeting of this virus to PD is subject to intense studies. TMV movement occurs in a non-encapsidated form and thus promises to reveal important host functions involved in the intra-and intercellular trafficking of RNA molecules. We have recently presented new evidence that the cell-to-cell trafficking of TMV RNA (vRNA) involves the formation and intracellular trafficking of distinct MP particles. Upon assembly, these particles detach from cortical microtubule (MT) sites and then move with the flow of ER through the cell. During passage the particles continue to undergo transient interactions with MT which may guide the particles to their destination. The comprehensive analysis of particle composition may lead to important insights into the regulation of RNA transport in plants and may also reveal potential similarities to RNA transport mechanisms in animals and humans. Addendum to: Sambade A, Brandner K, Hofmann C, Seemanpillai M, Mutterer J, Heinlein M. Transport of TMV movement protein particles associated with the targeting of RNA to plasmodesmata. Traffic 2008; In press.
ISSN:1559-2316
1559-2324
1559-2324
DOI:10.4161/psb.4.1.7253