Antenatal and Intrapartum Risk Factors for Seizures in Term Newborns: A Population-Based Study, California 1998-2002

Objective To assess antenatal and intrapartum risk factors for seizures occurring during the birth admission. Study design Using multivariable logistic regression analysis, we evaluated the association between maternal characteristics and birth admission seizures in a cohort of 2.3 million Californi...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of pediatrics 2009-01, Vol.154 (1), p.24-28.e1
Main Authors: Glass, Hannah C., MDCM, Pham, Trinh N., MA, Danielsen, Beate, PhD, Towner, Dena, MD, Glidden, David, PhD, Wu, Yvonne W., MD, MPH
Format: Article
Language:English
Subjects:
Biological and medical sciences
California - epidemiology
Chorioamnionitis - epidemiology
Delivery. Postpartum. Lactation
Female
General aspects
Gynecology. Andrology. Obstetrics
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Incidence
Infant, Newborn
Maternal Age
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Obstetric Labor Complications - epidemiology
Pediatrics
Pregnancy
Pregnancy in Diabetics - epidemiology
Risk Factors
Seizures - epidemiology
Seizures - ethnology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To assess antenatal and intrapartum risk factors for seizures occurring during the birth admission. Study design Using multivariable logistic regression analysis, we evaluated the association between maternal characteristics and birth admission seizures in a cohort of 2.3 million California children born at ≥36 weeks' gestation between 1998 and 2002 using the California Office of Statewide Planning and Development database containing birth certificates linked to infant and maternal hospital discharge abstracts. Results The incidence of seizures during the birth admission was 0.95/1000 live births. In an adjusted analysis, infants of women age 40 years and older who were nulliparous; had diabetes mellitus, intrapartum fever, or infection or delivered at ≥42 weeks had an increased risk of seizures. Infants of Hispanic and Asian mothers had a lower risk compared with infants of Caucasian mothers. Conclusions Several maternal antenatal and intrapartum factors increased the risk of seizures during the birth admission. Identifying and avoiding risks for neonatal seizures may lead to lower infant neurologic morbidity and mortality.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2008.07.008