Metabolomics and its application for non-invasive embryo assessment in IVF

Morphology and cleavage rate remain the mainstay of embryo assessment. However, a number of additional technologies for this application are under investigation. These include the measurement of glucose, lactate, pyruvate or amino acid levels in the embryo culture media, assessment of oxygen consump...

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Bibliographic Details
Published in:Molecular human reproduction 2008-12, Vol.14 (12), p.679-690
Main Authors: Botros, Lucy, Sakkas, Denny, Seli, Emre
Format: Article
Language:English
Subjects:
Amino Acids - metabolism
Animals
Biological and medical sciences
Culture Media - chemistry
Embryo Implantation
Embryo Transfer
Embryo, Mammalian - metabolism
Embryology: invertebrates and vertebrates. Teratology
Female
Fertilization in Vitro
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Humans
in vitro fertilization
Metabolomics
New Research Horizons
non-invasive embryo assessment
Pregnancy
Pyruvic Acid - metabolism
Spectrum Analysis - methods
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Summary:Morphology and cleavage rate remain the mainstay of embryo assessment. However, a number of additional technologies for this application are under investigation. These include the measurement of glucose, lactate, pyruvate or amino acid levels in the embryo culture media, assessment of oxygen consumption by the embryo, genomic and proteomic profiling, and most recently, analytical examination of the embryonic metabolome. As the number of assisted reproduction cycles increases worldwide, improvements in the ability to quickly and non-invasively identify the best embryos for transfer remain a critical goal for reproductive medicine. Recent studies suggest that metabolomic profiling of embryo culture media using optical and non-optical spectroscopies may provide a useful adjunct to the current embryo assessment strategies and provide insight into the phenotype of embryos with increasing reproductive potential.
ISSN:1360-9947
1460-2407
DOI:10.1093/molehr/gan066