MIB-1, Bcl-2 and p53 in odontogenic myxomas of the jaws

Odontogenic myxoma is a rare benign neoplasm occurring in the jaws. Microscopically, it is composed of spindle or stellate-shaped cells arranged in a mucinous matrix. In some cases (20%), odontogenic epithelial islands may be found. The Authors evaluated p53, MIB-1, and Bcl-2 expressed by the epithe...

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Bibliographic Details
Published in:Acta otorhino-laryngologica italica 2007-10, Vol.27 (5), p.237-242
Main Authors: IEZZI, G, PIATTELLI, A, RUBINI, C, ARTESE, L, FIORONI, M, CARINCI, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Genes, bcl-2 - genetics
Genes, p53 - genetics
Humans
Mandibular Neoplasms - genetics
Mandibular Neoplasms - pathology
Medical sciences
Middle Aged
Myxoma - genetics
Myxoma - pathology
Neoplasm Staging
Odontogenic Tumors - genetics
Odontogenic Tumors - pathology
Otorhinolaryngology. Stomatology
Tumors
Ubiquitin-Protein Ligases - genetics
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Summary:Odontogenic myxoma is a rare benign neoplasm occurring in the jaws. Microscopically, it is composed of spindle or stellate-shaped cells arranged in a mucinous matrix. In some cases (20%), odontogenic epithelial islands may be found. The Authors evaluated p53, MIB-1, and Bcl-2 expressed by the epithelial and stromal elements in 12 cases of odontogenic myxoma of the jaws. The cells of the odontogenic epithelium were positive for Bcl-2, p53 and MIB-1. The stromal cell showed a high positivity for MIB-1. Proliferation of both the epithelial and stromal components could be related to the growth of this odontogenic tumour.
ISSN:0392-100X
1827-675X